biostudies-literatureUnknown12(2)Novelli L<h4>Background</h4>Acute kidney injury (AKI) often complicates percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG). However, evidence on the incidence and prognostic impact of AKI after revascularisation for left main coronary artery disease (LMCAD) is scant, especially in terms of subsequent risk of persistent renal dysfunction (RD).<h4>Methods</h4>All consecutive patients undergoing PCI or CABG for LMCAD in two European institutions from 2015 to 2022 were enrolled. The coprimary endpoints were AKI, defined as an increase in serum creatinine (sCr) levels ≥0.3 mg/dL or increase by >50% as compared with baseline levels, and persistent RD, defined as a persistent increase of sCr at 1 year. The secondary endpoint was all-cause mortality. The risk of AKI with PCI vOpen hearte003527https://www.ebi.ac.uk/biostudies/studies/S-EPMC12603710biostudies-literatureLeft main percutaneous or surgical revascularisation and subsequent risk of transient and persistent renal dysfunction.PMC12603710Sanz-Sanchez JCantisani GReimers BTerzi RRegazzoli DColombo ADiez Gil JLLStefanini GOliva AFerrante GIaccarino AGasparini GLMangieri AChiarito MNovelli LMehran RMartinez Dolz LTorracca LBarbone ARomero JSfalseLeft main percutaneous or surgical revascularisation and subsequent risk of transient and persistent renal dysfunction.<h4>Background</h4>Acute kidney injury (AKI) often complicates percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG). However, evidence on the incidence and prognostic impact of AKI after revascularisation for left main coronary artery disease (LMCAD) is scant, especially in terms of subsequent risk of persistent renal dysfunction (RD).<h4>Methods</h4>All consecutive patients undergoing PCI or CABG for LMCAD in two European institutions from 2015 to 2022 were enrolled. The coprimary endpoints were AKI, defined as an increase in serum creatinine (sCr) levels ≥0.3 mg/dL or increase by >50% as compared with baseline levels, and persistent RD, defined as a persistent increase of sCr at 1 year. The secondary endpoint was all-cause mortality. The risk of AKI with PCI v2025-01-01T00:00:00Z2025 Nov2026-06-05T14:31:17.943Z2026-05-17T03:13:02.725ZS-EPMC126037104121382310.1136/openhrt-2025-003527