{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["100(12)"],"submitter":["Hemmer M"],"pubmed_abstract":["Pure red cell aplasia (PRCA) is the most frequent autoimmune cytopenia associated with thymic tumors (TTs). In a nationwide retrospective study, we included 41 patients (22 women, median age 62 years). At PRCA diagnosis, the mean hemoglobin level was 6.6 ± 2.1 g/dL, and the reticulocyte count was 6 ± 5 × 10<sup>9</sup>/L. PRCA was diagnosed before TT (8%, median delay 52 months), simultaneously (46%) or after TT (46%, median delay 34 months). Fourteen patients (34%) had definite Good syndrome. Thymectomy without immunosuppressive treatment provided a single sustainable PRCA response. Twenty-two patients (54%) experienced multiple PRCA relapses (Median 2). When PRCA was present at TT diagnosis, the risk of PRCA relapse was higher (p < 0.01), while TT staging, TT relapse, and Good syndrome w"],"journal":["American journal of hematology"],"pagination":["2230-2237"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12603890"],"repository":["biostudies-literature"],"pubmed_title":["Pure Red Cell Aplasia Associated With Thymic Tumors, a Nationwide Retrospective Study."],"pmcid":["PMC12603890"],"pubmed_authors":["Le Guenno G","Michel M","Lobbes H","Malphettes M","Moinard S","Lioger B","Viallard JF","Hemmer M","Lambotte O","Terriou L"],"additional_accession":[]},"is_claimable":false,"name":"Pure Red Cell Aplasia Associated With Thymic Tumors, a Nationwide Retrospective Study.","description":"Pure red cell aplasia (PRCA) is the most frequent autoimmune cytopenia associated with thymic tumors (TTs). In a nationwide retrospective study, we included 41 patients (22 women, median age 62 years). At PRCA diagnosis, the mean hemoglobin level was 6.6 ± 2.1 g/dL, and the reticulocyte count was 6 ± 5 × 10<sup>9</sup>/L. PRCA was diagnosed before TT (8%, median delay 52 months), simultaneously (46%) or after TT (46%, median delay 34 months). Fourteen patients (34%) had definite Good syndrome. Thymectomy without immunosuppressive treatment provided a single sustainable PRCA response. Twenty-two patients (54%) experienced multiple PRCA relapses (Median 2). When PRCA was present at TT diagnosis, the risk of PRCA relapse was higher (p < 0.01), while TT staging, TT relapse, and Good syndrome w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T15:02:20.49Z","creation":"2026-06-05T03:06:37.985Z"},"accession":"S-EPMC12603890","cross_references":{"pubmed":["40917040"],"doi":["10.1002/ajh.70068"]}}