{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Chen R"],"pubmed_abstract":["<i>Rhinopithecus roxellana</i> (<i>R. roxellana</i>) is an endangered primate species, and its infant survival rate in captivity is extremely low. In this study, we conducted a comparative analysis of the gut microbiota from 8 infants (14-18 days old), 12 juveniles/subadults (2-5 years old), and 12 adults of <i>R. roxellana</i> (7-14 years old), which were kept at the Nanjing Hongshan Forest Zoo in Nanjing City, Jiangsu Province, China. Through the 16S rRNA high-throughput sequencing, we found the gut microbiota richness and beta diversity in captive infant <i>R. roxellana</i> were significantly lower than those in the non-infant groups. The relative abundance of Firmicutes positively correlated with increasing age, whereas the abundance of <i>Shigella/Escherichia</i> and <i>Akkermansia</i> was significantly higher in the infants and exhibited a decreasing trend with age. Meanwhile, several potential pathogenic bacteria, including <i>Clostridium perfringens</i>, <i>Staphylococcus aureus</i>, and <i>Shigella flexneri,</i> among others, were found to be abundant in the infant samples following the cultivable bacteria isolation. This research preliminarily investigated the gut microbiota development of captive <i>R. roxellana</i> and provided a valuable theoretical foundation for improving the healthy breeding of captive infant <i>R. roxellana.</i>"],"journal":["Frontiers in veterinary science"],"pagination":["1683047"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12604355"],"repository":["biostudies-literature"],"pubmed_title":["The variation of gut microbiota in captive Sichuan golden snub-nosed monkeys (&lt;i&gt;Rhinopithecus roxellana&lt;/i&gt;) from infancy to adulthood."],"pmcid":["PMC12604355"],"pubmed_authors":["Liu X","Hong L","Deng C","Guo L","Wang S","Lv R","Wang G","Sun W","Xu X","Chen R","Li M","Liu G"],"additional_accession":[]},"is_claimable":false,"name":"The variation of gut microbiota in captive Sichuan golden snub-nosed monkeys (&lt;i&gt;Rhinopithecus roxellana&lt;/i&gt;) from infancy to adulthood.","description":"<i>Rhinopithecus roxellana</i> (<i>R. roxellana</i>) is an endangered primate species, and its infant survival rate in captivity is extremely low. In this study, we conducted a comparative analysis of the gut microbiota from 8 infants (14-18 days old), 12 juveniles/subadults (2-5 years old), and 12 adults of <i>R. roxellana</i> (7-14 years old), which were kept at the Nanjing Hongshan Forest Zoo in Nanjing City, Jiangsu Province, China. Through the 16S rRNA high-throughput sequencing, we found the gut microbiota richness and beta diversity in captive infant <i>R. roxellana</i> were significantly lower than those in the non-infant groups. The relative abundance of Firmicutes positively correlated with increasing age, whereas the abundance of <i>Shigella/Escherichia</i> and <i>Akkermansia</i> was significantly higher in the infants and exhibited a decreasing trend with age. Meanwhile, several potential pathogenic bacteria, including <i>Clostridium perfringens</i>, <i>Staphylococcus aureus</i>, and <i>Shigella flexneri,</i> among others, were found to be abundant in the infant samples following the cultivable bacteria isolation. This research preliminarily investigated the gut microbiota development of captive <i>R. roxellana</i> and provided a valuable theoretical foundation for improving the healthy breeding of captive infant <i>R. roxellana.</i>","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-05T12:51:32.812Z","creation":"2026-05-17T03:07:47.271Z"},"accession":"S-EPMC12604355","cross_references":{"pubmed":["41230461"],"doi":["10.3389/fvets.2025.1683047"]}}