biostudies-literatureChen XCarl Zeiss VisionTianjin Key Medical Discipline (Specialty) Construction Project929-938https://www.ebi.ac.uk/biostudies/studies/S-EPMC12604440biostudies-literatureUnknown103(8)<h4>Purpose</h4>To evaluate the effectiveness of 12 months of spectacle lens wear incorporating cylindrical annular refractive elements (CARE) in slowing myopia progression compared to single vision (SV) spectacle wear.<h4>Methods</h4>In an ongoing 2-year prospective, double-masked, multi-centre clinical trial, 240 Chinese children aged 6-13 years, spherical equivalent refractive error (SE) -0.75 D to -5.00 D were randomised to one of three groups of 80 participants each to wear: SV spectacle lens (N = 80), CARE spectacles (7 mm central clear zone surrounded by treatment zone incorporating CARE with mean surface power of +4.6 D) and CARE S (9 mm central clear zone surrounded by treatment zone comprising CARE with mean surface power of +3.8 D). Cycloplegic SE and axial length (AL) were measActa ophthalmologicaSlowing myopia progression with cylindrical annular refractive elements (CARE) spectacle lenses-Year 1 results from a 2-year prospective, multi-centre trial.PMC12604440TJYXZDXK-016AWu MYang YRifai KBoeck-Maier CYu CZhu YChen XWahl SLi LSankaridurg POhlendorf AfalseSlowing myopia progression with cylindrical annular refractive elements (CARE) spectacle lenses-Year 1 results from a 2-year prospective, multi-centre trial.<h4>Purpose</h4>To evaluate the effectiveness of 12 months of spectacle lens wear incorporating cylindrical annular refractive elements (CARE) in slowing myopia progression compared to single vision (SV) spectacle wear.<h4>Methods</h4>In an ongoing 2-year prospective, double-masked, multi-centre clinical trial, 240 Chinese children aged 6-13 years, spherical equivalent refractive error (SE) -0.75 D to -5.00 D were randomised to one of three groups of 80 participants each to wear: SV spectacle lens (N = 80), CARE spectacles (7 mm central clear zone surrounded by treatment zone incorporating CARE with mean surface power of +4.6 D) and CARE S (9 mm central clear zone surrounded by treatment zone comprising CARE with mean surface power of +3.8 D). Cycloplegic SE and axial length (AL) were meas2025-01-01T00:00:00Z2025 Dec2026-07-15T12:18:05.578Z2026-07-04T03:13:04.315ZS-EPMC126044403954860510.1111/aos.16795