biostudies-literatureYoung ACAnna-Greta Crafoords Stiftelse för Reumatologisk ForskningNHLBI NIH HHSe70127https://www.ebi.ac.uk/biostudies/studies/S-EPMC12606447biostudies-literatureUnknown7(11)<h4>Objective</h4>To evaluate the fecal metabolome in patients with early systemic sclerosis (SSc) compared with unaffected controls and to determine if altered metabolites are associated with specific bacterial genera in patients with early SSc.<h4>Methods</h4>Stool samples and clinical data were collected from 106 patients with early SSc and 79 unaffected control patients. Targeted metabolomics was performed on fecal samples using liquid chromatography mass spectrometry, and 16S ribosomal RNA gene sequencing was used to determine the microbial composition of fecal samples.<h4>Results</h4>Compared with unaffected controls, patients with early SSc had higher levels of nicotinamide, 5'-methylthioadenosine, and several short-chain fatty acids (SCFAs) including valeric acid, propionic acid, aACR open rheumatologyCharacterization of the Fecal Metabolome in Patients With Early Systemic Sclerosis.PMC12606447K23 HL15023720242014Matulionis NAndreasson KJacobs JPVolkmann ERYoung ACLabus JChristofk HfalseCharacterization of the Fecal Metabolome in Patients With Early Systemic Sclerosis.<h4>Objective</h4>To evaluate the fecal metabolome in patients with early systemic sclerosis (SSc) compared with unaffected controls and to determine if altered metabolites are associated with specific bacterial genera in patients with early SSc.<h4>Methods</h4>Stool samples and clinical data were collected from 106 patients with early SSc and 79 unaffected control patients. Targeted metabolomics was performed on fecal samples using liquid chromatography mass spectrometry, and 16S ribosomal RNA gene sequencing was used to determine the microbial composition of fecal samples.<h4>Results</h4>Compared with unaffected controls, patients with early SSc had higher levels of nicotinamide, 5'-methylthioadenosine, and several short-chain fatty acids (SCFAs) including valeric acid, propionic acid, a2025-01-01T00:00:00Z2025 Nov2026-05-17T03:19:24.64Z2026-05-17T03:12:21.854ZS-EPMC126064474122198910.1002/acr2.70127