{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Queener JA"],"pubmed_abstract":["High-valent metal intermediates play a key role in C(sp<sup>3</sup>)-H functionalization reactions in both enzymatic catalysis and organometallic chemistry. Despite its generality, this strategy often requires a single metal complex to efficiently mediate both hydrogen atom transfer and radical capture-a combination challenging to achieve. To overcome this limitation, we propose a decoupled approach, where separate high-valent metal complexes independently perform hydrogen atom transfer (HAT) and radical capture (RC). As a proof of concept, we leveraged the complementary reactivity of copper(iii) hydroxide (efficient for HAT) and copper(iii) fluoride (efficient for RC) to develop a decoupled <sup>18</sup>F-fluorination protocol. The distinct reactivity of copper(iii) hydroxide and copper(i"],"journal":["Chemical science"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12606465"],"repository":["biostudies-literature"],"pubmed_title":["Distinct hydrogen atom transfer and radical capture reactivity of copper(iii) OH/F complexes enables site-selective C(sp&lt;sup&gt;3&lt;/sup&gt;)-H &lt;sup&gt;18&lt;/sup&gt;F-fluorination."],"pmcid":["PMC12606465"],"pubmed_authors":["Tang J","Asor A","Fan J","Queener JA","Ball MAP","Zhang S"],"additional_accession":[]},"is_claimable":false,"name":"Distinct hydrogen atom transfer and radical capture reactivity of copper(iii) OH/F complexes enables site-selective C(sp&lt;sup&gt;3&lt;/sup&gt;)-H &lt;sup&gt;18&lt;/sup&gt;F-fluorination.","description":"High-valent metal intermediates play a key role in C(sp<sup>3</sup>)-H functionalization reactions in both enzymatic catalysis and organometallic chemistry. Despite its generality, this strategy often requires a single metal complex to efficiently mediate both hydrogen atom transfer and radical capture-a combination challenging to achieve. To overcome this limitation, we propose a decoupled approach, where separate high-valent metal complexes independently perform hydrogen atom transfer (HAT) and radical capture (RC). As a proof of concept, we leveraged the complementary reactivity of copper(iii) hydroxide (efficient for HAT) and copper(iii) fluoride (efficient for RC) to develop a decoupled <sup>18</sup>F-fluorination protocol. The distinct reactivity of copper(iii) hydroxide and copper(i","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T13:45:14.112Z","creation":"2026-05-17T03:13:33.405Z"},"accession":"S-EPMC12606465","cross_references":{"pubmed":["41235072"],"doi":["10.1039/d5sc06381g"]}}