{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang C"],"funding":["Yinfeng Plan of Tangdu hospital","National Natural Science Foundation of China"],"pagination":["155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12607142"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Osteoporosis (OP) could lead to the alteration of bone marrow microenvironment and non-homeostasis of hematopoiesis, which could increase the incidence of hematologic malignancies. However, whether myeloid-biased hematopoiesis occurred and contributed to the leukemogenesis under the condition of OP remains unclear.<h4>Results</h4>This study successfully induced a mouse model for OP by hindlimb unloading, which shows increased myeloid cells and decreased B cells in the peripheral blood (PB). Furthermore, our study demonstrates that the myeloid-biased subset of HSPCs (hematopoietic stem and progenitor cells) with reduced differentiation and apoptosis, including multipotent progenitor 3 (MPP3) and granulocyte-monocyte progenitors (GMPs), were expanded in the OP mice. The ex"],"journal":["Cell & bioscience"],"pubmed_title":["Single-cell transcriptome analysis profiles the enlarged subsets of myeloid-biased HSPCs with preleukemic characters in disuse osteoporosis mice."],"pmcid":["PMC12607142"],"funding_grant_id":["82200171","2021YFJH009"],"pubmed_authors":["Liu L","Lou D","Liang H","Gu F","Wan Z","Ji Y","Gao X","Qin W","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptome analysis profiles the enlarged subsets of myeloid-biased HSPCs with preleukemic characters in disuse osteoporosis mice.","description":"<h4>Background</h4>Osteoporosis (OP) could lead to the alteration of bone marrow microenvironment and non-homeostasis of hematopoiesis, which could increase the incidence of hematologic malignancies. However, whether myeloid-biased hematopoiesis occurred and contributed to the leukemogenesis under the condition of OP remains unclear.<h4>Results</h4>This study successfully induced a mouse model for OP by hindlimb unloading, which shows increased myeloid cells and decreased B cells in the peripheral blood (PB). Furthermore, our study demonstrates that the myeloid-biased subset of HSPCs (hematopoietic stem and progenitor cells) with reduced differentiation and apoptosis, including multipotent progenitor 3 (MPP3) and granulocyte-monocyte progenitors (GMPs), were expanded in the OP mice. The ex","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-10T03:14:32.067Z","creation":"2026-06-10T03:07:57.523Z"},"accession":"S-EPMC12607142","cross_references":{"pubmed":["41225641"],"doi":["10.1186/s13578-025-01499-3"]}}