{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin X"],"funding":["National Key R&amp;D Program of China","National Natural Science Foundation of China"],"pagination":["fcaf394"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12607259"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(6)"],"pubmed_abstract":["Vascular cognitive impairment no dementia (VCIND) represents cognitive deficits due to vascular causes, without meeting the criteria for dementia. Cognitive training has emerged as a safe and effective intervention for VCIND, though its underlying mechanisms remain obscure. This study investigates how subcortical VCIND and computerized cognitive training affect brain functional lateralization of the fronto-parietal network (FPN), whose functions are notably influenced by both VCIND and cognitive training. In a randomized, active-controlled design for VCIND patients, we assessed the resting-state functional lateralization index (LI) of the FPN and conducted neuropsychological assessments in VCIND training and control groups (<i>n</i> = 30 per group) at baseline, after a 7-week intervention "],"journal":["Brain communications"],"pubmed_title":["Cognitive training reorganizes lateralization of fronto-parietal network in vascular cognitive impairment."],"pmcid":["PMC12607259"],"funding_grant_id":["2022YFC3602600","81970996","82220108009"],"pubmed_authors":["Jin X","Xing Y","Du Y","Wang X","Ding J","Lyu B","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"Cognitive training reorganizes lateralization of fronto-parietal network in vascular cognitive impairment.","description":"Vascular cognitive impairment no dementia (VCIND) represents cognitive deficits due to vascular causes, without meeting the criteria for dementia. Cognitive training has emerged as a safe and effective intervention for VCIND, though its underlying mechanisms remain obscure. This study investigates how subcortical VCIND and computerized cognitive training affect brain functional lateralization of the fronto-parietal network (FPN), whose functions are notably influenced by both VCIND and cognitive training. In a randomized, active-controlled design for VCIND patients, we assessed the resting-state functional lateralization index (LI) of the FPN and conducted neuropsychological assessments in VCIND training and control groups (<i>n</i> = 30 per group) at baseline, after a 7-week intervention ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-10T05:19:25.379Z","creation":"2026-06-10T03:07:57.811Z"},"accession":"S-EPMC12607259","cross_references":{"pubmed":["41234528"],"doi":["10.1093/braincomms/fcaf394"]}}