biostudies-literatureJin XNational Key R&amp;D Program of ChinaNational Natural Science Foundation of Chinafcaf394https://www.ebi.ac.uk/biostudies/studies/S-EPMC12607259biostudies-literatureUnknown7(6)Vascular cognitive impairment no dementia (VCIND) represents cognitive deficits due to vascular causes, without meeting the criteria for dementia. Cognitive training has emerged as a safe and effective intervention for VCIND, though its underlying mechanisms remain obscure. This study investigates how subcortical VCIND and computerized cognitive training affect brain functional lateralization of the fronto-parietal network (FPN), whose functions are notably influenced by both VCIND and cognitive training. In a randomized, active-controlled design for VCIND patients, we assessed the resting-state functional lateralization index (LI) of the FPN and conducted neuropsychological assessments in VCIND training and control groups (<i>n</i> = 30 per group) at baseline, after a 7-week intervention Brain communicationsCognitive training reorganizes lateralization of fronto-parietal network in vascular cognitive impairment.PMC126072592022YFC36026008197099682220108009Jin XXing YDu YWang XDing JLyu BTang YfalseCognitive training reorganizes lateralization of fronto-parietal network in vascular cognitive impairment.Vascular cognitive impairment no dementia (VCIND) represents cognitive deficits due to vascular causes, without meeting the criteria for dementia. Cognitive training has emerged as a safe and effective intervention for VCIND, though its underlying mechanisms remain obscure. This study investigates how subcortical VCIND and computerized cognitive training affect brain functional lateralization of the fronto-parietal network (FPN), whose functions are notably influenced by both VCIND and cognitive training. In a randomized, active-controlled design for VCIND patients, we assessed the resting-state functional lateralization index (LI) of the FPN and conducted neuropsychological assessments in VCIND training and control groups (<i>n</i> = 30 per group) at baseline, after a 7-week intervention 2025-01-01T00:00:00Z20252026-06-10T05:19:25.379Z2026-06-10T03:07:57.811ZS-EPMC126072594123452810.1093/braincomms/fcaf394