biostudies-literatureUnknown9(4)Franco LWe aimed to develop evidence-based Pan American League of Associations for Rheumatology recommendations for the pharmacological treatment of systemic juvenile idiopathic arthritis (sJIA). An expert panel of paediatric rheumatologists from Latin America generated clinically meaningful research questions structured using the Population, Intervention, Comparator and Outcome (PICO) format, adhering to Grading of Recommendations Assessment, Development, and Evaluation methodology. A team of methodologists conducted a systematic literature review, extracted and summarized intervention effect estimates and graded the evidence quality. The JIA expert panel voted on each research question structured using the PICO format, requiring a minimum agreement of 70% among the voting members to formulate reRheumatology advances in practicerkaf087https://www.ebi.ac.uk/biostudies/studies/S-EPMC12607261biostudies-literaturePan American League of Associations for Rheumatology treatment recommendations for systemic juvenile idiopathic arthritis.PMC12607261Ringer AFaugier Fuentes EEstrella AIAppenzeller SGuarnizo Zuccardi PMorel ZRodrigues Fonseca AIbanez Estrella AFerrandiz MAHerrera CNSilva CAMarin Zucaro NMBrance MLBarzola MLEspada GEraso RArroyo Rivera ILFuentes EFCameto Caffa JACuttica RJJurado RMFranco LGutierrez-Suarez RTineo Rodriguez CPan American League of Associations for Rheumatology (PANLAR)Ramirez Stieben LAFernandez-Avila DGLeon BHTalesnik EFonseca ARRodriguez Tineo CJimenez Cruz KVBrun LRZuccardi PGfalsePan American League of Associations for Rheumatology treatment recommendations for systemic juvenile idiopathic arthritis.We aimed to develop evidence-based Pan American League of Associations for Rheumatology recommendations for the pharmacological treatment of systemic juvenile idiopathic arthritis (sJIA). An expert panel of paediatric rheumatologists from Latin America generated clinically meaningful research questions structured using the Population, Intervention, Comparator and Outcome (PICO) format, adhering to Grading of Recommendations Assessment, Development, and Evaluation methodology. A team of methodologists conducted a systematic literature review, extracted and summarized intervention effect estimates and graded the evidence quality. The JIA expert panel voted on each research question structured using the PICO format, requiring a minimum agreement of 70% among the voting members to formulate re2025-01-01T00:00:00Z20252026-06-05T03:15:42.62Z2026-06-05T03:06:46.332ZS-EPMC126072614123467210.1093/rap/rkaf087