{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rios-Delgado G"],"funding":["National Institute of Allergy and Infectious Diseases","Agence Nationale de la Recherche","U.S. Department of Agriculture","NIAID NIH HHS","National Science Foundation"],"pagination":["e0141525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12607789"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(11)"],"pubmed_abstract":["Bacterial regulatory RNAs (sRNAs) are commonly short non-coding RNAs that function as pleiotropic regulators by post-transcriptionally impacting mRNA stability and/or translation. They play significant roles in bacterial physiology and are typically expressed in response to specific environmental stimuli such as nutrient limitation. The bacterial pathogen <i>Staphylococcus aureus</i> faces decreased access to essential metal ions, including iron, in the mammalian host via a process called nutritional immunity. In response to host-mediated iron limitation, <i>S. aureus</i> expresses the sRNA IsrR, which coordinates an iron-sparing response by downregulating the expression of mRNAs coding for iron-requiring proteins or processes. Herein, we utilized MS2-Affinity Purification coupled with RNA"],"journal":["mBio"],"pubmed_title":["The iron-regulated small regulatory RNA IsrR modulates expression of genes utilized for dioxygen metabolism and heme synthesis in &lt;i&gt;Staphylococcus aureus&lt;/i&gt;."],"pmcid":["PMC12607789"],"funding_grant_id":["R01 AI139100","R01 AI155611","ANR-20-CE12-0021","ANR-10-IDEX-0002","AI155611","1750624","ANR-17-EURE-0023","ANR-20-SFRI-0012","NE-2248"],"pubmed_authors":["Lalaouna D","Kehl-Fie T","Rios-Delgado G","Boyd JM","McFarlane R","Kim J","Zheng V","Parker D"],"additional_accession":[]},"is_claimable":false,"name":"The iron-regulated small regulatory RNA IsrR modulates expression of genes utilized for dioxygen metabolism and heme synthesis in &lt;i&gt;Staphylococcus aureus&lt;/i&gt;.","description":"Bacterial regulatory RNAs (sRNAs) are commonly short non-coding RNAs that function as pleiotropic regulators by post-transcriptionally impacting mRNA stability and/or translation. They play significant roles in bacterial physiology and are typically expressed in response to specific environmental stimuli such as nutrient limitation. The bacterial pathogen <i>Staphylococcus aureus</i> faces decreased access to essential metal ions, including iron, in the mammalian host via a process called nutritional immunity. In response to host-mediated iron limitation, <i>S. aureus</i> expresses the sRNA IsrR, which coordinates an iron-sparing response by downregulating the expression of mRNAs coding for iron-requiring proteins or processes. Herein, we utilized MS2-Affinity Purification coupled with RNA","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T13:52:07.655Z","creation":"2026-05-17T03:13:02.351Z"},"accession":"S-EPMC12607789","cross_references":{"pubmed":["41042061"],"doi":["10.1128/mbio.01415-25"]}}