{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Weiblen C"],"funding":["Natural Sciences and Engineering Research Council of Canada","Canada First Research Excellence Fund","Mitacs"],"pagination":["e0153325"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12607906"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(11)"],"pubmed_abstract":["Proteobacterial methanotrophs are dependent on the oxidation of methane for ATP production and assimilation of carbon into biomass. Interestingly, some types of gammaproteobacterial methanotrophs thrive in oxygen-depleted zones of lakes and other aquatic ecosystems despite their reliance on oxygen to support methane oxidation. The model gammaproteobacterial methanotroph, <i>Methylomonas denitrificans</i> FJG1, oxidizes methane coupled to nitrate reduction under hypoxia and highly upregulates its expression of bacteriohemerythrin (Bhr). Bhr is a homolog of eukaryotic hemerythrin, which is a protein associated with oxygen binding. Ten <i>bhr</i> homologs were identified in the genome of <i>M. denitrificans</i> FJG1, requiring phylogenetic and gene expression analyses to pinpoint which homolo"],"journal":["mBio"],"pubmed_title":["Diverse bacteriohemerythrin genes of &lt;i&gt;Methylomonas denitrificans&lt;/i&gt; FJG1 provide insight into the survival and activity of methanotrophs in low oxygen ecosystems."],"pmcid":["PMC12607906"],"funding_grant_id":["FES","Discovery","Banting","Accelerate"],"pubmed_authors":["Weiblen C","Kleiner M","Kits KD","Stein LY","Sauvageau D"],"additional_accession":[]},"is_claimable":false,"name":"Diverse bacteriohemerythrin genes of &lt;i&gt;Methylomonas denitrificans&lt;/i&gt; FJG1 provide insight into the survival and activity of methanotrophs in low oxygen ecosystems.","description":"Proteobacterial methanotrophs are dependent on the oxidation of methane for ATP production and assimilation of carbon into biomass. Interestingly, some types of gammaproteobacterial methanotrophs thrive in oxygen-depleted zones of lakes and other aquatic ecosystems despite their reliance on oxygen to support methane oxidation. The model gammaproteobacterial methanotroph, <i>Methylomonas denitrificans</i> FJG1, oxidizes methane coupled to nitrate reduction under hypoxia and highly upregulates its expression of bacteriohemerythrin (Bhr). Bhr is a homolog of eukaryotic hemerythrin, which is a protein associated with oxygen binding. Ten <i>bhr</i> homologs were identified in the genome of <i>M. denitrificans</i> FJG1, requiring phylogenetic and gene expression analyses to pinpoint which homolo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-07-15T06:38:20.298Z","creation":"2026-07-02T03:08:42.944Z"},"accession":"S-EPMC12607906","cross_references":{"pubmed":["40996220"],"doi":["10.1128/mbio.01533-25"]}}