{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wen J"],"funding":["the Qinghai Provincial Natural Science Foundation for Young Scholars","National Natural Science Foundation of China"],"pagination":["10739"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12608487"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(21)"],"pubmed_abstract":["Tomato fruit malformation causes substantial yield and economic losses, but its molecular mechanisms are not well understood. This study compared floral traits of WT 'QT57' and malformed-fruit mutant 'QT2', integrated transcriptomic data, and qRT-PCR analysis to screen key candidate genes, and analyzed the pectinase gene family. The results found the 'QT2' mutant differed from WT 'QT57' in flower and fruit development. Expression analysis of CLAVATA-WUSCHEL pathway genes preliminarily validated the compensatory mechanism of <i>SlCRCa</i> and <i>SlCRCb</i> in 'QT2' malformed fruit. Six pectinase genes were identified as key candidates via RNA-seq and qRT-PCR analysis. Transcriptomic and qRT-PCR analyses of the pectinase gene family revealed their potential role in regulating tomato fruit ma"],"journal":["International journal of molecular sciences"],"pubmed_title":["Integrated Analysis of Transcriptomes and Pectinase Gene Families Reveals a Novel Pathway Mediating Tomato Fruit Malformation."],"pmcid":["PMC12608487"],"funding_grant_id":["2023-ZJ-953Q","No. 32460771"],"pubmed_authors":["Wen J","Zhong Q","Tao X","Zhou R","Li Q","Yan C"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Analysis of Transcriptomes and Pectinase Gene Families Reveals a Novel Pathway Mediating Tomato Fruit Malformation.","description":"Tomato fruit malformation causes substantial yield and economic losses, but its molecular mechanisms are not well understood. This study compared floral traits of WT 'QT57' and malformed-fruit mutant 'QT2', integrated transcriptomic data, and qRT-PCR analysis to screen key candidate genes, and analyzed the pectinase gene family. The results found the 'QT2' mutant differed from WT 'QT57' in flower and fruit development. Expression analysis of CLAVATA-WUSCHEL pathway genes preliminarily validated the compensatory mechanism of <i>SlCRCa</i> and <i>SlCRCb</i> in 'QT2' malformed fruit. Six pectinase genes were identified as key candidates via RNA-seq and qRT-PCR analysis. Transcriptomic and qRT-PCR analyses of the pectinase gene family revealed their potential role in regulating tomato fruit ma","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-17T03:20:49.533Z","creation":"2026-05-17T03:12:59.971Z"},"accession":"S-EPMC12608487","cross_references":{"pubmed":["41226771"],"doi":["10.3390/ijms262110739"]}}