{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Samdavid Thanapaul RJR"],"funding":["Karunya University"],"pagination":["10663"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12608917"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(21)"],"pubmed_abstract":["Chronic wounds present a major clinical challenge, often aggravated by infection and rising antimicrobial resistance. This study investigated the wound-healing efficacy of <i>Lobelia alsinoides</i> Lam., an ethnomedicinal herb, formulated as a topical ointment containing its ethanolic extract (LT). Phytochemical profiling identified high levels of phenolics, terpenoids, and tannins, while in vitro assays demonstrated strong antioxidant, broad-spectrum antimicrobial, and cytocompatible properties. Wound-healing potential was evaluated using excision and incision wound models in rats treated with 5% or 10% LT ointments, with Silverex™ as the reference standard. The 10% LT formulation significantly outperformed Silverex™, accelerating wound contraction (99.33 ± 0.55% by Day 16), shortening epithelialization time (16.1 ± 0.8 days), and enhancing tensile strength (837.36 ± 16.37 g; <i>p</i> < 0.001). Biochemical and histological analyses confirmed improved collagen deposition, extracellular matrix remodeling, and angiogenesis, without hepatic or renal toxicity. Overall, LT exhibited statistically superior wound-healing efficacy compared with Silverex™, supporting its potential as a safe, affordable, and sustainable phytotherapeutic alternative. These findings provide strong scientific validation for <i>L. alsinoides</i> as an evidence-based herbal candidate for integration into modern wound care, with future studies warranted to establish mechanistic and clinical efficacy in chronic and infected wounds."],"journal":["International journal of molecular sciences"],"pubmed_title":["Accelerated Full-Thickness Wound Healing by a Topical Ointment Formulated with &lt;i&gt;Lobelia alsinoides&lt;/i&gt; Lam. Ethanolic Extract."],"pmcid":["PMC12608917"],"funding_grant_id":["Silver Jubilee Fellowship (KU/AO/SJF/SL/2/2012)"],"pubmed_authors":["Nadar MSAM","Samdavid Thanapaul RJR","Manikandan SK","Paulraj MS"],"additional_accession":[]},"is_claimable":false,"name":"Accelerated Full-Thickness Wound Healing by a Topical Ointment Formulated with &lt;i&gt;Lobelia alsinoides&lt;/i&gt; Lam. Ethanolic Extract.","description":"Chronic wounds present a major clinical challenge, often aggravated by infection and rising antimicrobial resistance. This study investigated the wound-healing efficacy of <i>Lobelia alsinoides</i> Lam., an ethnomedicinal herb, formulated as a topical ointment containing its ethanolic extract (LT). Phytochemical profiling identified high levels of phenolics, terpenoids, and tannins, while in vitro assays demonstrated strong antioxidant, broad-spectrum antimicrobial, and cytocompatible properties. Wound-healing potential was evaluated using excision and incision wound models in rats treated with 5% or 10% LT ointments, with Silverex™ as the reference standard. The 10% LT formulation significantly outperformed Silverex™, accelerating wound contraction (99.33 ± 0.55% by Day 16), shortening epithelialization time (16.1 ± 0.8 days), and enhancing tensile strength (837.36 ± 16.37 g; <i>p</i> < 0.001). Biochemical and histological analyses confirmed improved collagen deposition, extracellular matrix remodeling, and angiogenesis, without hepatic or renal toxicity. Overall, LT exhibited statistically superior wound-healing efficacy compared with Silverex™, supporting its potential as a safe, affordable, and sustainable phytotherapeutic alternative. These findings provide strong scientific validation for <i>L. alsinoides</i> as an evidence-based herbal candidate for integration into modern wound care, with future studies warranted to establish mechanistic and clinical efficacy in chronic and infected wounds.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-18T03:19:26.941Z","creation":"2026-05-18T03:13:04.221Z"},"accession":"S-EPMC12608917","cross_references":{"pubmed":["41226698"],"doi":["10.3390/ijms262110663"]}}