biostudies-literatureUnknown14(21)Amjad ADiabetes mellitus is largely driven by oxidative stress that disrupts insulin signaling, leading to failure in insulin-mediated glucose absorption. Exploration of natural bioactive compounds is fueled by their promising role in correcting redox imbalance. This study aims to investigate the antidiabetic effect of the methanolic extract of <i>Praecitrullus fistulosus</i>, potentially by transcriptional modulation in streptozotocin-nicotinamide-induced diabetic rats. Male Wistar albino rats (<i>n</i> = 36) were assigned to six groups: normal control; diabetic control; standard drug group; and three treatment groups receiving <i>P. fistulosus</i> extract orally at doses of 200, 400, and 600 mg/kg body weight, respectively, for 30 consecutive days. Diabetes was induced in all groups, except forFoods (Basel, Switzerland)3764https://www.ebi.ac.uk/biostudies/studies/S-EPMC12609042biostudies-literature<i>Praecitrullus fistulosus</i> Extract Exhibits Antidiabetic Potential by Augmenting Insulin-Signaling Cascade, GLUT-4 and IRS-1, in Streptozotocin-Nicotinamide-Induced Diabetic Rats.PMC12609042Tahir SKAmjad ARaza QKhan AUfalse<i>Praecitrullus fistulosus</i> Extract Exhibits Antidiabetic Potential by Augmenting Insulin-Signaling Cascade, GLUT-4 and IRS-1, in Streptozotocin-Nicotinamide-Induced Diabetic Rats.Diabetes mellitus is largely driven by oxidative stress that disrupts insulin signaling, leading to failure in insulin-mediated glucose absorption. Exploration of natural bioactive compounds is fueled by their promising role in correcting redox imbalance. This study aims to investigate the antidiabetic effect of the methanolic extract of <i>Praecitrullus fistulosus</i>, potentially by transcriptional modulation in streptozotocin-nicotinamide-induced diabetic rats. Male Wistar albino rats (<i>n</i> = 36) were assigned to six groups: normal control; diabetic control; standard drug group; and three treatment groups receiving <i>P. fistulosus</i> extract orally at doses of 200, 400, and 600 mg/kg body weight, respectively, for 30 consecutive days. Diabetes was induced in all groups, except for2025-01-01T00:00:00Z2025 Nov2026-06-10T03:10:50.377Z2026-06-10T03:07:24.023ZS-EPMC126090424122773410.3390/foods14213764