{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(21)"],"submitter":["Kotlowska A"],"pubmed_abstract":["Maternal tobacco smoke exposure is associated with impaired fetal growth and long-term disease risk (DOHaD, Developmental Origins of Health and Disease). Whether placental steroid hormones are independently altered remains a matter of debate. We quantified six placental steroids (estradiol, estriol, estrone, progesterone, testosterone, and pregnanediol) using HPLC-Corona CAD in 70 deliveries (C = 30; PS = 20; AS = 20). Distributional differences were assessed with Kruskal-Wallis and pairwise Mann-Whitney tests with Benjamini-Hochberg (BH) control. Adjusted associations used log-linear OLS with HC3 robust SE: Model A (gestational age, maternal BMI, newborn sex) and Model B (Model A + birth weight), reported as percent change vs. controls, computed as (exp(β) - 1) × 100 with 95% CI. Secondar"],"journal":["International journal of molecular sciences"],"pagination":["10548"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12609261"],"repository":["biostudies-literature"],"pubmed_title":["Targeted Analysis of Placental Steroid Hormones in Relation to Maternal Tobacco Smoke Exposure: Early Markers Relevant to DOHaD (Developmental Origins of Health and Disease)."],"pmcid":["PMC12609261"],"pubmed_authors":["Kotlowska A","Stettner R","Szefer P","Fitzek S","Narkowicz S","Kielbratowska B"],"additional_accession":[]},"is_claimable":false,"name":"Targeted Analysis of Placental Steroid Hormones in Relation to Maternal Tobacco Smoke Exposure: Early Markers Relevant to DOHaD (Developmental Origins of Health and Disease).","description":"Maternal tobacco smoke exposure is associated with impaired fetal growth and long-term disease risk (DOHaD, Developmental Origins of Health and Disease). Whether placental steroid hormones are independently altered remains a matter of debate. We quantified six placental steroids (estradiol, estriol, estrone, progesterone, testosterone, and pregnanediol) using HPLC-Corona CAD in 70 deliveries (C = 30; PS = 20; AS = 20). Distributional differences were assessed with Kruskal-Wallis and pairwise Mann-Whitney tests with Benjamini-Hochberg (BH) control. Adjusted associations used log-linear OLS with HC3 robust SE: Model A (gestational age, maternal BMI, newborn sex) and Model B (Model A + birth weight), reported as percent change vs. controls, computed as (exp(β) - 1) × 100 with 95% CI. Secondar","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-17T03:09:17.516Z","creation":"2026-05-17T03:07:46.76Z"},"accession":"S-EPMC12609261","cross_references":{"pubmed":["41226586"],"doi":["10.3390/ijms262110548"]}}