{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Meng Q"],"funding":["Zhejiang Provincial Key Project of Aquaculture New Varieties Breeding"],"pagination":["3067"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12610153"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(21)"],"pubmed_abstract":["Heat stress typically suppresses systemic immunity in fish; however, its effects on the brain-an organ traditionally regarded as immune-privileged-remain unclear. In this study, we performed histopathological examination and RNA-seq analysis on the brains of juvenile largemouth bass (<i>Micropterus salmoides</i>) exposed to control (28 °C) and elevated (36.5 °C) water temperatures for 8 weeks. Histological analysis revealed distinct cytoarchitectural and pathological changes in specific brain regions. RNA-seq analysis identified a total of 1240 differentially expressed genes, with 22 heat shock protein genes notably showing significant up-regulation. The immune system-associated genes emerged as the most prominently affected category. Gene set enrichment analysis (GSEA) based on Kyoto Ency"],"journal":["Animals : an open access journal from MDPI"],"pubmed_title":["Long-Term Heat Stress Triggers Immune Activation and Cell Death Remodeling in the Brain of Largemouth Bass (&lt;i&gt;Micropterus salmoides&lt;/i&gt;)."],"pmcid":["PMC12610153"],"funding_grant_id":["2021C02069-2"],"pubmed_authors":["Peng Y","Li J","Guo J","Meng Q","Tao Y","Li F","Huang H","Xun C","Chen X","Zhou F"],"additional_accession":[]},"is_claimable":false,"name":"Long-Term Heat Stress Triggers Immune Activation and Cell Death Remodeling in the Brain of Largemouth Bass (&lt;i&gt;Micropterus salmoides&lt;/i&gt;).","description":"Heat stress typically suppresses systemic immunity in fish; however, its effects on the brain-an organ traditionally regarded as immune-privileged-remain unclear. In this study, we performed histopathological examination and RNA-seq analysis on the brains of juvenile largemouth bass (<i>Micropterus salmoides</i>) exposed to control (28 °C) and elevated (36.5 °C) water temperatures for 8 weeks. Histological analysis revealed distinct cytoarchitectural and pathological changes in specific brain regions. RNA-seq analysis identified a total of 1240 differentially expressed genes, with 22 heat shock protein genes notably showing significant up-regulation. The immune system-associated genes emerged as the most prominently affected category. Gene set enrichment analysis (GSEA) based on Kyoto Ency","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-17T03:10:49.885Z","creation":"2026-05-17T03:07:51.148Z"},"accession":"S-EPMC12610153","cross_references":{"pubmed":["41227398"],"doi":["10.3390/ani15213067"]}}