biostudies-literatureUnknown26(21)Pineda-Migranas JACervical cancer remains a significant public health priority, particularly in low- and middle-income countries. In this context, liquid biopsy has emerged as a minimally invasive method for detecting and monitoring molecular biomarkers, offering advantages over traditional screening approaches. This systematic review included 21 studies published between 2015 and 2025 and was conducted in accordance with the PRISMA 2020 statement. The analysis examined the role of serum cytokines, circulating microRNAs (miRNAs), and circulating cell-free HPV DNA (cfHPV-DNA) in patients with cervical cancer or high-grade intraepithelial lesions. Circulating miRNAs-particularly miR-21, miR-29a, and miR-34a-are consistently associated with recurrence, tumor progression, and reduced survival. However, their imInternational journal of molecular sciences10503https://www.ebi.ac.uk/biostudies/studies/S-EPMC12610596biostudies-literatureLiquid Biopsy Biomarkers for Cervical Cancer: A Systematic Review.PMC12610596Cortes-Malagon EMde Los Angeles Romero-Tlalolini MAcosta-Altamirano GCortes-Ortiz IASierra-Martinez MPineda-Migranas JABravata-Alcantara JCfalseLiquid Biopsy Biomarkers for Cervical Cancer: A Systematic Review.Cervical cancer remains a significant public health priority, particularly in low- and middle-income countries. In this context, liquid biopsy has emerged as a minimally invasive method for detecting and monitoring molecular biomarkers, offering advantages over traditional screening approaches. This systematic review included 21 studies published between 2015 and 2025 and was conducted in accordance with the PRISMA 2020 statement. The analysis examined the role of serum cytokines, circulating microRNAs (miRNAs), and circulating cell-free HPV DNA (cfHPV-DNA) in patients with cervical cancer or high-grade intraepithelial lesions. Circulating miRNAs-particularly miR-21, miR-29a, and miR-34a-are consistently associated with recurrence, tumor progression, and reduced survival. However, their im2025-01-01T00:00:00Z2025 Oct2026-05-17T03:15:10.697Z2026-05-17T03:08:04.028ZS-EPMC126105964122654110.3390/ijms262110503