{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhan S"],"funding":["Nanjing Drum Tower Hospital Clinical Research Special Fund Projec","National Natural Science Foundation of China","Nanjing Drum Tower Hospital Clinical Research Special Fund Project"],"pagination":["211"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12613488"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(1)"],"pubmed_abstract":["<h4>Background</h4>Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by dysregulated inflammatory response lacking reliable diagnosis biomarkers and therapy targets. Extracellular vesicles (EVs)-derived cargo as biomarkers and mediators of SLE have garnered significant attention, however, quantitative inflammatory protein profile of SLE EVs remain uncovered.<h4>Objective</h4>Current study focuses on exploring the inflammatory protein landscape of SLE serum EVs via quantitative proximity extension assay (PEA) and evaluates their diagnostic utility for SLE and lupus nephritis (LN).<h4>Methods</h4>In this cross-sectional study, we first utilized PEA to profile inflammatory proteins derived from serum EVs in 101 individuals, including 70 SLE patients and 33 healt"],"journal":["Arthritis research & therapy"],"pubmed_title":["Inflammation-related proteomics of extracellular vesicles as novel biomarkers for systemic lupus erythematosus revealed by proximity extension assay."],"pmcid":["PMC12613488"],"funding_grant_id":["2023-JCYJ-QP-25","2024-LCYJ-MS-11","82202600"],"pubmed_authors":["Dou H","Zhan S","Zhu Y","Zhou S","Yang P","Ge M","Wang Z","Shen H","Xu Y","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Inflammation-related proteomics of extracellular vesicles as novel biomarkers for systemic lupus erythematosus revealed by proximity extension assay.","description":"<h4>Background</h4>Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by dysregulated inflammatory response lacking reliable diagnosis biomarkers and therapy targets. Extracellular vesicles (EVs)-derived cargo as biomarkers and mediators of SLE have garnered significant attention, however, quantitative inflammatory protein profile of SLE EVs remain uncovered.<h4>Objective</h4>Current study focuses on exploring the inflammatory protein landscape of SLE serum EVs via quantitative proximity extension assay (PEA) and evaluates their diagnostic utility for SLE and lupus nephritis (LN).<h4>Methods</h4>In this cross-sectional study, we first utilized PEA to profile inflammatory proteins derived from serum EVs in 101 individuals, including 70 SLE patients and 33 healt","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T12:31:00.193Z","creation":"2026-05-16T03:12:50.509Z"},"accession":"S-EPMC12613488","cross_references":{"pubmed":["41233846"],"doi":["10.1186/s13075-025-03681-x"]}}