biostudies-literatureZhan SNanjing Drum Tower Hospital Clinical Research Special Fund ProjecNational Natural Science Foundation of ChinaNanjing Drum Tower Hospital Clinical Research Special Fund Project211https://www.ebi.ac.uk/biostudies/studies/S-EPMC12613488biostudies-literatureUnknown27(1)<h4>Background</h4>Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by dysregulated inflammatory response lacking reliable diagnosis biomarkers and therapy targets. Extracellular vesicles (EVs)-derived cargo as biomarkers and mediators of SLE have garnered significant attention, however, quantitative inflammatory protein profile of SLE EVs remain uncovered.<h4>Objective</h4>Current study focuses on exploring the inflammatory protein landscape of SLE serum EVs via quantitative proximity extension assay (PEA) and evaluates their diagnostic utility for SLE and lupus nephritis (LN).<h4>Methods</h4>In this cross-sectional study, we first utilized PEA to profile inflammatory proteins derived from serum EVs in 101 individuals, including 70 SLE patients and 33 healtArthritis research & therapyInflammation-related proteomics of extracellular vesicles as novel biomarkers for systemic lupus erythematosus revealed by proximity extension assay.PMC126134882023-JCYJ-QP-252024-LCYJ-MS-1182202600Dou HZhan SZhu YZhou SYang PGe MWang ZShen HXu YSong YfalseInflammation-related proteomics of extracellular vesicles as novel biomarkers for systemic lupus erythematosus revealed by proximity extension assay.<h4>Background</h4>Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by dysregulated inflammatory response lacking reliable diagnosis biomarkers and therapy targets. Extracellular vesicles (EVs)-derived cargo as biomarkers and mediators of SLE have garnered significant attention, however, quantitative inflammatory protein profile of SLE EVs remain uncovered.<h4>Objective</h4>Current study focuses on exploring the inflammatory protein landscape of SLE serum EVs via quantitative proximity extension assay (PEA) and evaluates their diagnostic utility for SLE and lupus nephritis (LN).<h4>Methods</h4>In this cross-sectional study, we first utilized PEA to profile inflammatory proteins derived from serum EVs in 101 individuals, including 70 SLE patients and 33 healt2025-01-01T00:00:00Z2025 Nov2026-06-05T12:31:00.193Z2026-05-16T03:12:50.509ZS-EPMC126134884123384610.1186/s13075-025-03681-x