{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ho CT"],"funding":["American Heart Association","University of North Carolina","NCI NIH HHS","NIGMS NIH HHS","NIH HHS"],"pagination":["e202503068"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12614643"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["224(12)"],"pubmed_abstract":["Neuronal morphogenesis depends on extracellular guidance cues accurately instructing intracellular cytoskeletal remodeling. Here, we describe a novel role of the actin binding protein coronin 1A (Coro1A) in neuronal morphogenesis, where it mediates responses to the axon guidance cue netrin-1. We found that Coro1A localizes to growth cones and filopodial structures and is required for netrin-dependent axon turning, branching, and corpus callosum development. We previously discovered that Coro1A interacts with TRIM67, a brain-enriched E3 ubiquitin ligase that binds the netrin receptor DCC, and is also required for netrin-mediated neuronal morphogenesis. Loss of Coro1A and loss of TRIM67 shared similar phenotypes, suggesting that they may function together in the same netrin pathway. A Coro1A"],"journal":["The Journal of cell biology"],"pubmed_title":["Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis."],"pmcid":["PMC12614643"],"funding_grant_id":["R35GM130312","P30 CA016086","R35GM135160","R35 GM130312","R35 GM135160","906429"],"pubmed_authors":["Lukasik K","Evans EB","Ho CT","Shah A","Gupton SL","Bear JE","Temple B","O'Shaughnessy EC","Hsu CH"],"additional_accession":[]},"is_claimable":false,"name":"Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis.","description":"Neuronal morphogenesis depends on extracellular guidance cues accurately instructing intracellular cytoskeletal remodeling. Here, we describe a novel role of the actin binding protein coronin 1A (Coro1A) in neuronal morphogenesis, where it mediates responses to the axon guidance cue netrin-1. We found that Coro1A localizes to growth cones and filopodial structures and is required for netrin-dependent axon turning, branching, and corpus callosum development. We previously discovered that Coro1A interacts with TRIM67, a brain-enriched E3 ubiquitin ligase that binds the netrin receptor DCC, and is also required for netrin-mediated neuronal morphogenesis. Loss of Coro1A and loss of TRIM67 shared similar phenotypes, suggesting that they may function together in the same netrin pathway. A Coro1A","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T12:34:40.908Z","creation":"2026-05-16T03:12:40.661Z"},"accession":"S-EPMC12614643","cross_references":{"pubmed":["41085995"],"doi":["10.1083/jcb.202503068"]}}