{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Islam MT"],"funding":["Bill and Melinda Gates Foundation"],"pagination":["e0013644"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12614799"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(11)"],"pubmed_abstract":["<h4>Background</h4>This study aimed to estimate the prevalence of shigellosis among household contacts (HHCs) using data from the 'Enterics for Global Health (EFGH)' study, conducted at seven Asian and African countries.<h4>Methods</h4>In Bangladesh, the EFGH study was conducted in Maniknagar, Dhaka, to determine the burden of shigellosis among children aged 6-35 months. HHCs of Shigella-positive patients (index cases) were enrolled in this study. Stool specimens form contacts were collected within 7 days of enrollment of index cases and culture and qPCR were performed. Sociodemographic and behavioral information were obtained to identify risk factors.<h4>Results</h4>A total of 400 HHCs of 118 index cases were enrolled, of which 36 (9%) were positive for Shigella spp. by culture, while qPCR revealed 21% (42/200) of contacts had Shigella infections. Individuals who failed to reheat meals before consumption had a two-fold higher risk of shigellosis compared to those who reheated meals, although other sociodemographic and behavioral factors did not show any significant association.<h4>Conclusions</h4>The study revealed a high burden of asymptomatic Shigella-infected individuals, emphasizing the need for systematic surveillance to assess the burden and develop effective preventive strategies to prevent the spread of the disease."],"journal":["PLoS neglected tropical diseases"],"pubmed_title":["Prevalence of Shigellosis among household contacts of index cases in the EFGH catchment area, Dhaka, Bangladesh."],"pmcid":["PMC12614799"],"funding_grant_id":["INV-045988"],"pubmed_authors":["Hossen MI","Qadri F","Firoj MG","Rajib MNH","Ahmmed F","Bhuiyan AI","Qudrat-E-Khuda S","Islam MT","Bhuiyan MTR","Biswas PK","Raz SMAA","Ireen M","Mosharraf MP","Khanam F"],"additional_accession":[]},"is_claimable":false,"name":"Prevalence of Shigellosis among household contacts of index cases in the EFGH catchment area, Dhaka, Bangladesh.","description":"<h4>Background</h4>This study aimed to estimate the prevalence of shigellosis among household contacts (HHCs) using data from the 'Enterics for Global Health (EFGH)' study, conducted at seven Asian and African countries.<h4>Methods</h4>In Bangladesh, the EFGH study was conducted in Maniknagar, Dhaka, to determine the burden of shigellosis among children aged 6-35 months. HHCs of Shigella-positive patients (index cases) were enrolled in this study. Stool specimens form contacts were collected within 7 days of enrollment of index cases and culture and qPCR were performed. Sociodemographic and behavioral information were obtained to identify risk factors.<h4>Results</h4>A total of 400 HHCs of 118 index cases were enrolled, of which 36 (9%) were positive for Shigella spp. by culture, while qPCR revealed 21% (42/200) of contacts had Shigella infections. Individuals who failed to reheat meals before consumption had a two-fold higher risk of shigellosis compared to those who reheated meals, although other sociodemographic and behavioral factors did not show any significant association.<h4>Conclusions</h4>The study revealed a high burden of asymptomatic Shigella-infected individuals, emphasizing the need for systematic surveillance to assess the burden and develop effective preventive strategies to prevent the spread of the disease.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T13:33:56.904Z","creation":"2026-05-17T03:13:19.616Z"},"accession":"S-EPMC12614799","cross_references":{"pubmed":["41196885"],"doi":["10.1371/journal.pntd.0013644"]}}