biostudies-literatureYang JRNational Science and Technology CouncilChina Medical University87https://www.ebi.ac.uk/biostudies/studies/S-EPMC12619232biostudies-literatureUnknown17(1)Vibrio vulnificus is a marine pathogen that is a significant cause of foodborne infections, leading to chronic diseases and primary septicemia. Wound infections caused by this bacterium can result in serious complications such as ulceration and tissue necrosis. The pathogenesis of V. vulnificus is influenced by quorum sensing and the secondary messenger cyclic diguanylate (c-di-GMP). The levels of c-di-GMP inside the cell are controlled by its synthesizer, diguanylate cyclase, and its degrader, phosphodiesterase. The phosphodiesterase VieA serves as a key transcriptional regulator in V. cholerae's virulence. However, the function of its diguanylate cyclase partner in locally controlling c-di-GMP-mediated virulence regulation in V. vulnificus remains unclear. This study identified a diguanyGut pathogensThe diguanylate cyclase and phosphodiesterase locally regulate the virulence factors in Vibrio vulnificus.PMC12619232NSTC 114-2311-B-039-002CMU113-MF-99Chen KTLai SJYang JRChen YWfalseThe diguanylate cyclase and phosphodiesterase locally regulate the virulence factors in Vibrio vulnificus.Vibrio vulnificus is a marine pathogen that is a significant cause of foodborne infections, leading to chronic diseases and primary septicemia. Wound infections caused by this bacterium can result in serious complications such as ulceration and tissue necrosis. The pathogenesis of V. vulnificus is influenced by quorum sensing and the secondary messenger cyclic diguanylate (c-di-GMP). The levels of c-di-GMP inside the cell are controlled by its synthesizer, diguanylate cyclase, and its degrader, phosphodiesterase. The phosphodiesterase VieA serves as a key transcriptional regulator in V. cholerae's virulence. However, the function of its diguanylate cyclase partner in locally controlling c-di-GMP-mediated virulence regulation in V. vulnificus remains unclear. This study identified a diguany2025-01-01T00:00:00Z2025 Nov2026-06-05T13:00:22.301Z2026-05-17T03:13:19.633ZS-EPMC126192324123943810.1186/s13099-025-00769-2