biostudies-literatureUnknown47(1)Yang XLupus nephritis (LN) is a frequent and serious complication of systemic lupus erythemosus (SLE). Both innate and adaptive immunity play essential roles in the initiation and progression of LN. B-lymphocyte stimulator (BLYS) and a proliferation-inducing ligand (APRIL), members of the tumor necrosis factor superfamily, bind to receptors such as B-cell activating factor receptor 3 (BR3), transmembrane activator and CAML interactor protein (TACI), and B-cell maturation antigen (BCMA). BLYS and APRIL are often overexpressed in LN, showing a positive correlation with disease activity. Therapeutic targeting of BLYS/APRIL has demonstrated efficacy in reducing LN activity. Traditional immunosuppressants often have multiple contraindications and side effects due to their broad immune-suppressing effRenal failure2561791https://www.ebi.ac.uk/biostudies/studies/S-EPMC12624907biostudies-literatureBiological targeted therapy for lupus nephritis-the role of BLYS and APRIL.PMC12624907Yang XLv JChen QLiu XJDeng QLiu SZeng YZhou YWang YWen DLi LfalseBiological targeted therapy for lupus nephritis-the role of BLYS and APRIL.Lupus nephritis (LN) is a frequent and serious complication of systemic lupus erythemosus (SLE). Both innate and adaptive immunity play essential roles in the initiation and progression of LN. B-lymphocyte stimulator (BLYS) and a proliferation-inducing ligand (APRIL), members of the tumor necrosis factor superfamily, bind to receptors such as B-cell activating factor receptor 3 (BR3), transmembrane activator and CAML interactor protein (TACI), and B-cell maturation antigen (BCMA). BLYS and APRIL are often overexpressed in LN, showing a positive correlation with disease activity. Therapeutic targeting of BLYS/APRIL has demonstrated efficacy in reducing LN activity. Traditional immunosuppressants often have multiple contraindications and side effects due to their broad immune-suppressing eff2025-01-01T00:00:00Z2025 Dec2026-06-05T16:33:38.428Z2026-05-18T03:13:03.591ZS-EPMC126249074124910110.1080/0886022X.2025.2561791