{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Grady KL"],"funding":["NHLBI NIH HHS"],"pagination":["345-355"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12626348"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(4)"],"pubmed_abstract":["<h4>Background</h4>Few study authors examined factors influencing health-related quality of life (HRQOL) early after left ventricular assist device (LVAD) implantation.<h4>Objective</h4>The purpose of this study was to determine whether 5 novel self-report measures and other variables were significantly associated with overall HRQOL at 3 months after LVAD surgery.<h4>Methods</h4>Patients were recruited between October 26, 2016, and February 29, 2020, from 12 US sites. Data were collected before LVAD implantation and at 3 months post LVAD implantation. Overall HRQOL measures included the Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) overall summary score (OSS) and EuroQol 5-dimension- 3L visual analog scale. Potential factors associated with overall HRQOL included 5 novel self-report measures (Satisfaction with Treatment, Being Bothered by VAD Self-care and Limitations, VAD Team Communication, Self-efficacy regarding VAD Self-care, and Stigma), and demographic and clinical characteristics. Statistics included regression analyses.<h4>Results</h4>Of enrollees, 242 completed self-report measures at baseline, and 142 completed measures 3 months postoperatively. Patients were 55 ± 13 years old, with 21% female, 24% non-White, 39% high school or lower educated, and 47% destination therapy. Using the KCCQ-12 OSS, higher Satisfaction with Treatment was associated with a higher KCCQ-12 OSS; Being Bothered by VAD Self-care and Limitations, high school or lower education, chest incision pain, cardiac dysrhythmias within 3 postoperative months, and peripheral edema were associated with a worse KCCQ-12 OSS ( R2 = 0.524). Factors associated with a worse 3-month EuroQol 5-dimension-3L visual analog scale were female sex, adverse events within 3 months post implantation (cardiac dysrhythmias, bleeding, and venous thrombosis), and chest incision pain ( R2 = 0.229). No factors were associated with a higher EuroQol 5-dimension-3L visual analog scale score at 3 months.<h4>Conclusions</h4>Two novel measures, demographics, postimplantation adverse events, and symptoms were associated with post-LVAD KCCQ-12 OSS early after surgery."],"journal":["The Journal of cardiovascular nursing"],"pubmed_title":["Association of Novel Ventricular Assist Device Self-report Measures With Overall Health-Related Quality of Life."],"pmcid":["PMC12626348"],"funding_grant_id":["R01 HL130502"],"pubmed_authors":["Adler E","Beiser DG","Rich J","Denfeld QE","Lee CS","Klein L","Murks C","Bedjeti K","Grady KL","Burns JL","McIlvennan CK","Hahn EA","Allen LA","Yancy C","Ruo B","Lindenfeld J","Walsh MN","Stehlik J","Kirklin JK","Kiernan M","Cella D","Teuteberg J","Pham DT"],"additional_accession":[]},"is_claimable":false,"name":"Association of Novel Ventricular Assist Device Self-report Measures With Overall Health-Related Quality of Life.","description":"<h4>Background</h4>Few study authors examined factors influencing health-related quality of life (HRQOL) early after left ventricular assist device (LVAD) implantation.<h4>Objective</h4>The purpose of this study was to determine whether 5 novel self-report measures and other variables were significantly associated with overall HRQOL at 3 months after LVAD surgery.<h4>Methods</h4>Patients were recruited between October 26, 2016, and February 29, 2020, from 12 US sites. Data were collected before LVAD implantation and at 3 months post LVAD implantation. Overall HRQOL measures included the Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) overall summary score (OSS) and EuroQol 5-dimension- 3L visual analog scale. Potential factors associated with overall HRQOL included 5 novel self-report measures (Satisfaction with Treatment, Being Bothered by VAD Self-care and Limitations, VAD Team Communication, Self-efficacy regarding VAD Self-care, and Stigma), and demographic and clinical characteristics. Statistics included regression analyses.<h4>Results</h4>Of enrollees, 242 completed self-report measures at baseline, and 142 completed measures 3 months postoperatively. Patients were 55 ± 13 years old, with 21% female, 24% non-White, 39% high school or lower educated, and 47% destination therapy. Using the KCCQ-12 OSS, higher Satisfaction with Treatment was associated with a higher KCCQ-12 OSS; Being Bothered by VAD Self-care and Limitations, high school or lower education, chest incision pain, cardiac dysrhythmias within 3 postoperative months, and peripheral edema were associated with a worse KCCQ-12 OSS ( R2 = 0.524). Factors associated with a worse 3-month EuroQol 5-dimension-3L visual analog scale were female sex, adverse events within 3 months post implantation (cardiac dysrhythmias, bleeding, and venous thrombosis), and chest incision pain ( R2 = 0.229). No factors were associated with a higher EuroQol 5-dimension-3L visual analog scale score at 3 months.<h4>Conclusions</h4>Two novel measures, demographics, postimplantation adverse events, and symptoms were associated with post-LVAD KCCQ-12 OSS early after surgery.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul-Aug 01","modification":"2026-06-05T19:09:50.109Z","creation":"2026-05-20T03:14:14.037Z"},"accession":"S-EPMC12626348","cross_references":{"pubmed":["39259580"],"doi":["10.1097/JCN.0000000000001129","10.1097/jcn.0000000000001129"]}}