{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(1)"],"submitter":["Gabriel-Segard T"],"pubmed_abstract":["Anorexia nervosa (AN) is the most severe and life-threatening eating disorder. Its pathophysiology remains largely unknown, and no effective treatment currently exists for severe forms of the disease. Gut microbiota (GM) dysbiosis has been consistently reported in AN; however, no study has yet considered the role of the microbiota within the full spectrum of AN symptoms. To investigate the direct involvement of the microbiota in disease symptoms, we developed a murine model of fecal microbiota transplantation (FMT), using germ-free BALB/c mice colonized with fecal samples from well-characterized AN patients and healthy controls. Physiological, organ, and behavioral parameters were systematically monitored. We found that key AN-related features (including food restriction, anxiety-like beha"],"journal":["Gut microbes"],"pagination":["2563701"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12626428"],"repository":["biostudies-literature"],"pubmed_title":["Anorexia nervosa symptoms are induced after specific gut microbiota dysbiosis transfer in germ-free mice."],"pmcid":["PMC12626428"],"pubmed_authors":["Gabriel-Segard T","Duquesnoy M","Maximin E","Mondot S","Jacota M","Paul S","Dicembre M","Blais A","Hanachi M","Philippe C","Dore J","Rabot S","Blottiere HM","Heberden C","Naudon L","Lapaque N"],"additional_accession":[]},"is_claimable":false,"name":"Anorexia nervosa symptoms are induced after specific gut microbiota dysbiosis transfer in germ-free mice.","description":"Anorexia nervosa (AN) is the most severe and life-threatening eating disorder. Its pathophysiology remains largely unknown, and no effective treatment currently exists for severe forms of the disease. Gut microbiota (GM) dysbiosis has been consistently reported in AN; however, no study has yet considered the role of the microbiota within the full spectrum of AN symptoms. To investigate the direct involvement of the microbiota in disease symptoms, we developed a murine model of fecal microbiota transplantation (FMT), using germ-free BALB/c mice colonized with fecal samples from well-characterized AN patients and healthy controls. Physiological, organ, and behavioral parameters were systematically monitored. We found that key AN-related features (including food restriction, anxiety-like beha","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T19:17:38.308Z","creation":"2026-05-20T03:14:45.274Z"},"accession":"S-EPMC12626428","cross_references":{"pubmed":["41239983"],"doi":["10.1080/19490976.2025.2563701"]}}