biostudies-literatureUnknown54Yechuan DengThe increasing prevalence of acute traumatic injuries caused by traffic accidents, and natural disasters presents multifaceted challenges such as hemorrhages in irregular wounds and being susceptible to microbes. Herein, in situ point-of-care electrospun Zein/Polyvinylpyrrolidone nanofiber bioactive dressings coordinated with tannic acid-based copper nanoparticles (CTZP) are prepared. CTZP exhibits rapid hemostasis performance in rat tail amputation model. And in vitro blood coagulation experiment verifies that CTZP can achieve blood coagulation within 1 min. It has been found that CTZP can activate platelet through the expression of TBXAS1 via PI3K-Akt signaling pathway. Furthermore, the in vitro tube forming assay present that CTZP has an angiogenetic promotion effecBioactive materials371-386https://www.ebi.ac.uk/biostudies/studies/S-EPMC12628142biostudies-literaturePoint-of-care treatment of acute skin wound by portable in-situ electrospinning nanofiber dressings with rapid hemostasis, anti-infection, and angiogenesis effects.PMC12628142Liu XQian WQiu JXing MZhao LFeng JYechuan DengCao YGuan SYe KfalsePoint-of-care treatment of acute skin wound by portable in-situ electrospinning nanofiber dressings with rapid hemostasis, anti-infection, and angiogenesis effects.The increasing prevalence of acute traumatic injuries caused by traffic accidents, and natural disasters presents multifaceted challenges such as hemorrhages in irregular wounds and being susceptible to microbes. Herein, in situ point-of-care electrospun Zein/Polyvinylpyrrolidone nanofiber bioactive dressings coordinated with tannic acid-based copper nanoparticles (CTZP) are prepared. CTZP exhibits rapid hemostasis performance in rat tail amputation model. And in vitro blood coagulation experiment verifies that CTZP can achieve blood coagulation within 1 min. It has been found that CTZP can activate platelet through the expression of TBXAS1 via PI3K-Akt signaling pathway. Furthermore, the in vitro tube forming assay present that CTZP has an angiogenetic promotion effec2025-01-01T00:00:00Z2025 Dec2026-06-06T06:57:00.119Z2026-06-06T03:06:15.652ZS-EPMC126281424126835010.1016/j.bioactmat.2025.08.020