biostudies-literatureFalcao BPCzech Ministry of Education, Youth, and SportsThe National Biodiversity CenterUniversita degli Studi di Napoli Federico IIMinistry of Education, Youth and Sports of the Czech RepublicCzech Ministry of Education, Youth, and Sports (MEYS)Grant Agency of the University of South BohemiaCzech Science Foundatione0256624https://www.ebi.ac.uk/biostudies/studies/S-EPMC12628792biostudies-literatureUnknown91(11)Siderophores are low-molecular-weight compounds excreted by microorganisms to acquire iron and possibly to monopolize iron resource to achieve competitive advantage over other strains, or to trade for other substrates in mutualistic relationships. Siderophores that employ β-hydroxy-aspartate (β-OH-Asp) for iron chelation can undergo UV-mediated photolytic cleavage, simultaneously reducing Fe³⁺ to Fe²⁺. Photolytic siderophores can promote algal-bacterial mutualism, where the bacteria provide iron in exchange for dissolved organic carbon. We present a comprehensive characterization of cyanochelin B, a photolytic β-OH-Asp-containing siderophore produced by the filamentous cyanobacterium <i>Leptolyngbya</i> sp. NIES-3755. Combining nuclear magnetic resonance, high-resolutApplied and environmental microbiologyCyanochelin B: a cyanobacterium-produced siderophore with photolytic properties that negate iron monopolization in UV light.PMC12628792126/2024/POP JAK project "Photomachines" - CZ.02.01.01/00/22_008/0004624LM2023069OP JAK project “Photomachines” - CZ.02.01.01/00/22_008/0004624121 06/21/2022 (IR0000035)22-05478SFRA 2022Kuta JHrouzek PStenclova LDi Matteo VFalcao BPMares JCostantino VUrajova PKozlikova-Zapomelova EYerena JAMGalica TEsposito GMangoni AfalseCyanochelin B: a cyanobacterium-produced siderophore with photolytic properties that negate iron monopolization in UV light.Siderophores are low-molecular-weight compounds excreted by microorganisms to acquire iron and possibly to monopolize iron resource to achieve competitive advantage over other strains, or to trade for other substrates in mutualistic relationships. Siderophores that employ β-hydroxy-aspartate (β-OH-Asp) for iron chelation can undergo UV-mediated photolytic cleavage, simultaneously reducing Fe³⁺ to Fe²⁺. Photolytic siderophores can promote algal-bacterial mutualism, where the bacteria provide iron in exchange for dissolved organic carbon. We present a comprehensive characterization of cyanochelin B, a photolytic β-OH-Asp-containing siderophore produced by the filamentous cyanobacterium <i>Leptolyngbya</i> sp. NIES-3755. Combining nuclear magnetic resonance, high-resolut2025-01-01T00:00:00Z2025 Nov2026-05-19T03:21:03.251Z2026-05-19T03:11:47.103ZS-EPMC126287924109099810.1128/aem.02566-24