{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shu H"],"funding":["Natural Science Foundation of Jiangxi Province","Postdoctoral Research Foundation of China","Science Fund for Distinguished Young Scholars of Jiangxi Province","National Natural Science Foundation of China"],"pagination":["474"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12629007"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["Background
The role of additional intravenous thrombolysis (IVT) during posterior circulation ischemic stroke (PCIS) treatment remains unclear. The aim of this study is to assess the efficacy and safety of additional IVT for PCIS.Method
PubMed, EMBASE, and the Cochrane library were searched to obtain studies relevant to IVT alone, endovascular treatment (EVT) alone or EVT + IVT in the treatment of PCIS from their inception through February 2025. Primary efficacy outcome was modified Rankin Scale (mRS) 0-2 at 90 days. Symptomatic intracranial haemorrhage (sICH) and mortality at 90 days were the primary safety outcomes. Network meta-analysis (NMA) based on Bayesian approach was employed to assess and rank the therapeutic efficacy and safety of IVT alone, EVT alone and EVT + I"],"journal":["BMC neurology"],"pubmed_title":["Revascularization treatment for posterior circulation ischemic stroke: a systematic review and network meta-analysis."],"pmcid":["PMC12629007"],"funding_grant_id":["2022M721452","20224BAB216074","82403635","20232BAB206085"],"pubmed_authors":["Zhang W","Lv F","Long Z","Yan T","Shu H","Liang M","Hu P","Tu W"],"additional_accession":[]},"is_claimable":false,"name":"Revascularization treatment for posterior circulation ischemic stroke: a systematic review and network meta-analysis.","description":"Background
The role of additional intravenous thrombolysis (IVT) during posterior circulation ischemic stroke (PCIS) treatment remains unclear. The aim of this study is to assess the efficacy and safety of additional IVT for PCIS.Method
PubMed, EMBASE, and the Cochrane library were searched to obtain studies relevant to IVT alone, endovascular treatment (EVT) alone or EVT + IVT in the treatment of PCIS from their inception through February 2025. Primary efficacy outcome was modified Rankin Scale (mRS) 0-2 at 90 days. Symptomatic intracranial haemorrhage (sICH) and mortality at 90 days were the primary safety outcomes. Network meta-analysis (NMA) based on Bayesian approach was employed to assess and rank the therapeutic efficacy and safety of IVT alone, EVT alone and EVT + I","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T17:31:49.376Z","creation":"2026-06-05T03:07:36.49Z"},"accession":"S-EPMC12629007","cross_references":{"pubmed":["41257736"],"doi":["10.1186/s12883-025-04469-x"]}}