{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vliex LMM"],"funding":["NWO-CCC","Dutch Research Council (NWO)"],"pagination":["2580693"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12629329"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Antibiotic-induced perturbations of the gut microbiome can be long-lasting and potentially affect host metabolic health. Strategies supporting microbial resilience are needed to mitigate the negative impact of antibiotics. We investigated the potential of 2'-fucosyllactose (2'-FL) supplementation after vancomycin use in a double-blind placebo-controlled randomized intervention among adults with overweight/obesity. Participants received oral vancomycin for seven days followed by 2'-FL or placebo for eight weeks. At baseline, after vancomycin use and after supplementation, glucose tolerance, insulin sensitivity, plasma lipids, glucagon-like peptide 1, inflammatory cytokines, fecal short-chain fatty acids (SCFAs) and branched-chain fatty acids were analyzed. Gut microbial diversity, compositi"],"journal":["Gut microbes"],"pubmed_title":["2'-Fucosyllactose supplementation results in a transient improvement in gut microbial resilience after vancomycin use in adults with overweight or obesity: a randomized, double-blind, placebo-controlled intervention."],"pmcid":["PMC12629329"],"funding_grant_id":["ALWCC.2017.003"],"pubmed_authors":["Monzel E","Nauta A","Blaak EE","Penders J","Holst JJ","Barnett D","Fassarella M","Zoetendal EG","Vliex LMM","Oudhuis GJ"],"additional_accession":[]},"is_claimable":false,"name":"2'-Fucosyllactose supplementation results in a transient improvement in gut microbial resilience after vancomycin use in adults with overweight or obesity: a randomized, double-blind, placebo-controlled intervention.","description":"Antibiotic-induced perturbations of the gut microbiome can be long-lasting and potentially affect host metabolic health. Strategies supporting microbial resilience are needed to mitigate the negative impact of antibiotics. We investigated the potential of 2'-fucosyllactose (2'-FL) supplementation after vancomycin use in a double-blind placebo-controlled randomized intervention among adults with overweight/obesity. Participants received oral vancomycin for seven days followed by 2'-FL or placebo for eight weeks. At baseline, after vancomycin use and after supplementation, glucose tolerance, insulin sensitivity, plasma lipids, glucagon-like peptide 1, inflammatory cytokines, fecal short-chain fatty acids (SCFAs) and branched-chain fatty acids were analyzed. Gut microbial diversity, compositi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T18:43:19.676Z","creation":"2026-05-20T03:13:57.819Z"},"accession":"S-EPMC12629329","cross_references":{"pubmed":["41243448"],"doi":["10.1080/19490976.2025.2580693"]}}