{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Philouze P"],"funding":["National League Against Cancer","LabEx PRIMES","Nuovo-Soldati Research Foundation","French National Research Agency"],"pagination":["102595"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12630086"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63"],"pubmed_abstract":["Objectives
Non-HPV-induced squamous cell carcinomas (SCC) of the oropharynx have a poorer prognosis than HPV-induced cancers because they are more radio- and chemoresistant. Currently, no predictive biomarker exists for survival outcome in this type of tumor. NRF2 is a nuclear transcription factor that regulates the expression of cytoprotective genes, and peroxiredoxin 6 is one of the proteins regulated by NRF2. Both are potentially involved in the resistance to treatments as they play a central role in the response to oxidative stress.Material and methods
In a retrospective cohort study of 53 patients with advanced HPV-negative squamous cell carcinomas of the oropharynx, we studied the correlation between clinical characteristics, response to treatment (surgery + radiother"],"journal":["Translational oncology"],"pubmed_title":["Nuclear factor E2 p45-related factor (NRF2) and peroxiredoxin 6 tissular expression as prognostic biomarkers for advanced HPV-negative squamous cell carcinoma of the oropharynx."],"pmcid":["PMC12630086"],"funding_grant_id":["ANR-11-LABX-0063","ANR-11-IDEX-0007"],"pubmed_authors":["Benzerdjeb N","Kobler A","Ceruse P","Alphonse G","Burgy M","Soumboundou M","Wozny AS","Philouze P","Malesys C","Rodriguez-Lafrasse C","Jung AC"],"additional_accession":[]},"is_claimable":false,"name":"Nuclear factor E2 p45-related factor (NRF2) and peroxiredoxin 6 tissular expression as prognostic biomarkers for advanced HPV-negative squamous cell carcinoma of the oropharynx.","description":"Objectives
Non-HPV-induced squamous cell carcinomas (SCC) of the oropharynx have a poorer prognosis than HPV-induced cancers because they are more radio- and chemoresistant. Currently, no predictive biomarker exists for survival outcome in this type of tumor. NRF2 is a nuclear transcription factor that regulates the expression of cytoprotective genes, and peroxiredoxin 6 is one of the proteins regulated by NRF2. Both are potentially involved in the resistance to treatments as they play a central role in the response to oxidative stress.Material and methods
In a retrospective cohort study of 53 patients with advanced HPV-negative squamous cell carcinomas of the oropharynx, we studied the correlation between clinical characteristics, response to treatment (surgery + radiother","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T17:35:51.568Z","creation":"2026-05-19T03:12:05.208Z"},"accession":"S-EPMC12630086","cross_references":{"pubmed":["41187427"],"doi":["10.1016/j.tranon.2025.102595"]}}