biostudies-literaturePhilouze PNational League Against CancerLabEx PRIMESNuovo-Soldati Research FoundationFrench National Research Agency102595https://www.ebi.ac.uk/biostudies/studies/S-EPMC12630086biostudies-literatureUnknown63<h4>Objectives</h4>Non-HPV-induced squamous cell carcinomas (SCC) of the oropharynx have a poorer prognosis than HPV-induced cancers because they are more radio- and chemoresistant. Currently, no predictive biomarker exists for survival outcome in this type of tumor. NRF2 is a nuclear transcription factor that regulates the expression of cytoprotective genes, and peroxiredoxin 6 is one of the proteins regulated by NRF2. Both are potentially involved in the resistance to treatments as they play a central role in the response to oxidative stress.<h4>Material and methods</h4>In a retrospective cohort study of 53 patients with advanced HPV-negative squamous cell carcinomas of the oropharynx, we studied the correlation between clinical characteristics, response to treatment (surgery + radiotherTranslational oncologyNuclear factor E2 p45-related factor (NRF2) and peroxiredoxin 6 tissular expression as prognostic biomarkers for advanced HPV-negative squamous cell carcinoma of the oropharynx.PMC12630086ANR-11-LABX-0063ANR-11-IDEX-0007Benzerdjeb NKobler ACeruse PAlphonse GBurgy MSoumboundou MWozny ASPhilouze PMalesys CRodriguez-Lafrasse CJung ACfalseNuclear factor E2 p45-related factor (NRF2) and peroxiredoxin 6 tissular expression as prognostic biomarkers for advanced HPV-negative squamous cell carcinoma of the oropharynx.<h4>Objectives</h4>Non-HPV-induced squamous cell carcinomas (SCC) of the oropharynx have a poorer prognosis than HPV-induced cancers because they are more radio- and chemoresistant. Currently, no predictive biomarker exists for survival outcome in this type of tumor. NRF2 is a nuclear transcription factor that regulates the expression of cytoprotective genes, and peroxiredoxin 6 is one of the proteins regulated by NRF2. Both are potentially involved in the resistance to treatments as they play a central role in the response to oxidative stress.<h4>Material and methods</h4>In a retrospective cohort study of 53 patients with advanced HPV-negative squamous cell carcinomas of the oropharynx, we studied the correlation between clinical characteristics, response to treatment (surgery + radiother2025-01-01T00:00:00Z2025 Nov2026-06-05T17:35:51.568Z2026-05-19T03:12:05.208ZS-EPMC126300864118742710.1016/j.tranon.2025.102595