{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Sulaiman JE"],"pubmed_abstract":["<i>Akkermansia muciniphila</i> and <i>Bifidobacterium</i> spp. are major probiotic strains that have been shown to improve host metabolism and treat metabolic diseases. Previous studies have proposed formulating these probiotics as a therapeutic product to improve efficacy, but how they affect the growth and protein expression of each other in response to different nutrient environments remains unexplored. Here, we performed label-free quantitative proteomics on <i>A. muciniphila</i> and two <i>Bifidobacterium</i> species, <i>Bifidobacterium longum</i> and <i>Bifidobacterium breve</i>, in the presence of different carbon sources. <i>Akkermansia muciniphila</i> displayed distinct growth profiles when co-cultured with <i>B. breve</i> and <i>B. longum</i> in media containing monosaccharides ("],"journal":["Frontiers in microbiology"],"pagination":["1666747"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12631272"],"repository":["biostudies-literature"],"pubmed_title":["Proteomic study of &lt;i&gt;Akkermansia muciniphila&lt;/i&gt; and &lt;i&gt;Bifidobacterium&lt;/i&gt; species co-culture under different carbon sources."],"pmcid":["PMC12631272"],"pubmed_authors":["Li JHW","Lai Y","Wang S","Tsim KWK","Lai KL","Cheng KKY","Yutong DY","Sulaiman JE","Lam H","Zhan Y"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic study of &lt;i&gt;Akkermansia muciniphila&lt;/i&gt; and &lt;i&gt;Bifidobacterium&lt;/i&gt; species co-culture under different carbon sources.","description":"<i>Akkermansia muciniphila</i> and <i>Bifidobacterium</i> spp. are major probiotic strains that have been shown to improve host metabolism and treat metabolic diseases. Previous studies have proposed formulating these probiotics as a therapeutic product to improve efficacy, but how they affect the growth and protein expression of each other in response to different nutrient environments remains unexplored. Here, we performed label-free quantitative proteomics on <i>A. muciniphila</i> and two <i>Bifidobacterium</i> species, <i>Bifidobacterium longum</i> and <i>Bifidobacterium breve</i>, in the presence of different carbon sources. <i>Akkermansia muciniphila</i> displayed distinct growth profiles when co-cultured with <i>B. breve</i> and <i>B. longum</i> in media containing monosaccharides (","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-05T17:26:41.894Z","creation":"2026-05-19T03:11:55.622Z"},"accession":"S-EPMC12631272","cross_references":{"pubmed":["41277960"],"doi":["10.3389/fmicb.2025.1666747"]}}