{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(45)"],"submitter":["Nguyen D"],"pubmed_abstract":["This research performed a structure-activity relationship (SAR) study, which involved the synthesis of 16 (<i>2R/S</i>)-6-PFVNs and evaluating their cytotoxic effects on the HeLa cell line. This investigation concentrated on the length of the prenyl side chain at the C-6 position of the A-ring and the substitution patterns of the methoxy and hydroxy groups on the B-ring. Accordingly, several (<i>2R/S</i>)-6-PFVNs were identified as having strong cytotoxic effects on HeLa cells. Among them, (<i>2R/S</i>)-6-(3,3-diethylallyl)-naringenin (6-DEANG) emerged as a standout candidate, demonstrating an IC<sub>50</sub> value of 12 μM and a selectivity index (SI) exceeding 10. Furthermore, the synergistic effect of (<i>2R</i>)-6-DEANG and (<i>2S</i>)-6-DEANG on the treatment of HeLa cells with (<i>2R"],"journal":["ACS omega"],"pagination":["53827-53847"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12631367"],"repository":["biostudies-literature"],"pubmed_title":["The Synergistic Cytotoxic Effect of the Two Enantiomers of 6‑Prenylflavanones in the HeLa Cell Line."],"pmcid":["PMC12631367"],"pubmed_authors":["Truong N","Ngoc TT","Pham PV","Nguyen H","Tran B","Nguyen D","Thi PL","Tran Q","Thuy Nguyen LT","Thi Nguyen MT","Hoa LT"],"additional_accession":[]},"is_claimable":false,"name":"The Synergistic Cytotoxic Effect of the Two Enantiomers of 6‑Prenylflavanones in the HeLa Cell Line.","description":"This research performed a structure-activity relationship (SAR) study, which involved the synthesis of 16 (<i>2R/S</i>)-6-PFVNs and evaluating their cytotoxic effects on the HeLa cell line. This investigation concentrated on the length of the prenyl side chain at the C-6 position of the A-ring and the substitution patterns of the methoxy and hydroxy groups on the B-ring. Accordingly, several (<i>2R/S</i>)-6-PFVNs were identified as having strong cytotoxic effects on HeLa cells. Among them, (<i>2R/S</i>)-6-(3,3-diethylallyl)-naringenin (6-DEANG) emerged as a standout candidate, demonstrating an IC<sub>50</sub> value of 12 μM and a selectivity index (SI) exceeding 10. Furthermore, the synergistic effect of (<i>2R</i>)-6-DEANG and (<i>2S</i>)-6-DEANG on the treatment of HeLa cells with (<i>2R","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T06:57:15.307Z","creation":"2026-06-06T03:06:21.05Z"},"accession":"S-EPMC12631367","cross_references":{"pubmed":["41280777"],"doi":["10.1021/acsomega.5c02553"]}}