{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(45)"],"submitter":["Dhurjad P"],"pubmed_abstract":["Conformational diversity in conopeptides, Be828 and Li833, for which sequences are identified from <i>Conus betulinus</i> and <i>Conus lividus</i> has been explored in the present study. Be828 and Li833 have 23-membered rings with two consecutive prolines at positions 2/3 and 4/5, respectively, an unusual phenomenon observed in contryphans. These peptides provided an excellent scope to probe distinct conformational states, i.e., <i>cis</i>-<i>trans</i> isomerization around Xaa-Pro and Pro-Pro bonds. NMR analysis revealed that Be828 exists as a single trans (C1-P2)/trans (P2-P3) conformation, whereas Li833 exists in four distinct conformers across the consecutive proline bonds. Studies on synthetic analogues disclosed that the conformational heterogeneity in Li833 is influenced by the const"],"journal":["ACS omega"],"pagination":["54030-54038"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12631695"],"repository":["biostudies-literature"],"pubmed_title":["Conformational Heterogeneity of Pro-Pro Containing 23-Membered Ring Conopeptides by NMR."],"pmcid":["PMC12631695"],"pubmed_authors":["Dhurjad P","Sonti R","Shaik K","Dannarm SR","Wanjari P"],"additional_accession":[]},"is_claimable":false,"name":"Conformational Heterogeneity of Pro-Pro Containing 23-Membered Ring Conopeptides by NMR.","description":"Conformational diversity in conopeptides, Be828 and Li833, for which sequences are identified from <i>Conus betulinus</i> and <i>Conus lividus</i> has been explored in the present study. Be828 and Li833 have 23-membered rings with two consecutive prolines at positions 2/3 and 4/5, respectively, an unusual phenomenon observed in contryphans. These peptides provided an excellent scope to probe distinct conformational states, i.e., <i>cis</i>-<i>trans</i> isomerization around Xaa-Pro and Pro-Pro bonds. NMR analysis revealed that Be828 exists as a single trans (C1-P2)/trans (P2-P3) conformation, whereas Li833 exists in four distinct conformers across the consecutive proline bonds. Studies on synthetic analogues disclosed that the conformational heterogeneity in Li833 is influenced by the const","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T18:43:10.935Z","creation":"2026-05-20T03:13:53.595Z"},"accession":"S-EPMC12631695","cross_references":{"pubmed":["41280801"],"doi":["10.1021/acsomega.5c05404"]}}