biostudies-literatureChen XKey Research and Development Program of ZhejiangScience and Technology Innovation Project of the General Administration of Sport of ChinaFundamental Research Funds for the Central UniversitiesZhejiang Provincial Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaShanxi-Zheda Institute of Advanced Materials and Chemical EngineeringR&D Program of ZhejiangHundred Talents Program of Zhejiang Universitye10702https://www.ebi.ac.uk/biostudies/studies/S-EPMC12631874biostudies-literatureUnknown12(43)Hydrogel-assisted soft biosensors have emerged as transformative platforms for multimodal physiological monitoring in amphibious environments. However, developing instant underwater adhesive, scalable manufacturing, and robust interfaces for long-term continuous multi-physiological bioelectronics remains challenging. Here, a universal and facile fabrication strategy is presented that overcomes these limitations through molecular entanglement engineering to fabricate instant underwater adhesion hydrogel interfaces, exhibiting rapid, strong interfacial toughness over 230 J•m^-2 within 10 s. Besides, a roll-to-roll scalable manufacturing protocol for practical transformation is established. The hydrogel interfaces with tissue-like softness ≈109 kPa, enabling seamless multimodal biosAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Underwater Instant Adhesive Hydrogel Interfaces for Robust Biosensing on Diverse Species.PMC12631874LTGY23E0500022024C03259524755732023C03196226-2024-00074226-2024-001722022YFA1205301188020*194231701/1132023C0119024KJCX0742023YFC281150052090030520900312022SZ-TD0122022YFA1205300Peng YXia ZFeng XFang WZhu XChen XHe LHuang LMing XWang JXu ZfalseUnderwater Instant Adhesive Hydrogel Interfaces for Robust Biosensing on Diverse Species.Hydrogel-assisted soft biosensors have emerged as transformative platforms for multimodal physiological monitoring in amphibious environments. However, developing instant underwater adhesive, scalable manufacturing, and robust interfaces for long-term continuous multi-physiological bioelectronics remains challenging. Here, a universal and facile fabrication strategy is presented that overcomes these limitations through molecular entanglement engineering to fabricate instant underwater adhesion hydrogel interfaces, exhibiting rapid, strong interfacial toughness over 230 J•m^-2 within 10 s. Besides, a roll-to-roll scalable manufacturing protocol for practical transformation is established. The hydrogel interfaces with tissue-like softness ≈109 kPa, enabling seamless multimodal bios2025-01-01T00:00:00Z2025 Nov2026-06-05T17:51:37.844Z2026-05-19T03:11:32.296ZS-EPMC126318744084979810.1002/advs.202510702