biostudies-literatureSong RScientific and Technological Innovation Programs of Higher Education Institutions in Shanxithe National Natural Science Foundation of ChinaBasic Research Program of Shanxi Province1015https://www.ebi.ac.uk/biostudies/studies/S-EPMC12632012biostudies-literatureUnknown30(1)Increasing evidence suggests that C1q/tumor necrosis factor-related proteins (CTRPs), as the adipokine superfamily, are secreted by adipose tissues. They play an important role in diabetic cardiovascular pathology. Diabetic vascular complications pose a significant threat to human health and are the primary cause of disability and mortality in diabetes. Adipose tissue dysfunction, including secretion and dysfunction of adipokines, is closely associated with diabetic vasculopathy. However, the expression levels of CTRPs show heterogeneity in different pathophysiological states, and their potential mechanisms of action have not been elucidated. Therefore, this review aims to summarize and discuss the differences in circulating expression of CTRPs in diabetic patients, as well as their roles and mechanisms in diabetic vasculopathy, to offer new insights and targets for the prevention and treatment of diabetic vasculopathy.European journal of medical researchThe mechanism of C1q/TNF-related proteins (CTRPs) in atherosclerosis associated with type 2 diabetes mellitus.PMC12632012No.82000799202303021222335No. 202303021211209No.2022L145Zhang GLiu JZhu YSong RZhang YHu WCheng RGao JWu FGong WfalseThe mechanism of C1q/TNF-related proteins (CTRPs) in atherosclerosis associated with type 2 diabetes mellitus.Increasing evidence suggests that C1q/tumor necrosis factor-related proteins (CTRPs), as the adipokine superfamily, are secreted by adipose tissues. They play an important role in diabetic cardiovascular pathology. Diabetic vascular complications pose a significant threat to human health and are the primary cause of disability and mortality in diabetes. Adipose tissue dysfunction, including secretion and dysfunction of adipokines, is closely associated with diabetic vasculopathy. However, the expression levels of CTRPs show heterogeneity in different pathophysiological states, and their potential mechanisms of action have not been elucidated. Therefore, this review aims to summarize and discuss the differences in circulating expression of CTRPs in diabetic patients, as well as their roles and mechanisms in diabetic vasculopathy, to offer new insights and targets for the prevention and treatment of diabetic vasculopathy.2025-01-01T00:00:00Z2025 Oct2026-05-19T03:20:24.905Z2026-05-19T03:11:50.726ZS-EPMC126320124125816010.1186/s40001-025-03188-w