{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["He S"],"funding":["NIGMS NIH HHS"],"pubmed_abstract":["Biomolecular condensates spatially organize cellular functions, but the regulation of their size, number, dissolution, and re-condensation is poorly understood. The pyrenoid, an algal biomolecular condensate that mediates one-third of global CO<sub>2</sub> fixation, typically exists as one large condensate per chloroplast, but during cell division it transiently dissolves and reconfigures into multiple smaller condensates. Here, we identify a kinase, KEY1, in the model alga <i>Chlamydomonas reinhardtii</i> that regulates pyrenoid condensate size and number dynamics throughout the cell cycle and is necessary for normal pyrenoid function and growth. Unlike wild type, <i>key1</i> mutant cells have multiple smaller condensates throughout the cell cycle that fail to dissolve during cell divisio"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.10.09.681382"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12632510"],"repository":["biostudies-literature"],"pubmed_title":["Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions."],"pmcid":["PMC12632510"],"funding_grant_id":["R01 GM140032"],"pubmed_authors":["Kayser-Browne A","Jonikas MC","Lemma LM","Hennacy JH","Rai AK","Wingreen NS","Brangwynne CP","He G","Wang C","Bunday L","Martinez-Calvo A","Wang L","He S","Wang Q","Ergun SL"],"additional_accession":[]},"is_claimable":false,"name":"Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions.","description":"Biomolecular condensates spatially organize cellular functions, but the regulation of their size, number, dissolution, and re-condensation is poorly understood. The pyrenoid, an algal biomolecular condensate that mediates one-third of global CO<sub>2</sub> fixation, typically exists as one large condensate per chloroplast, but during cell division it transiently dissolves and reconfigures into multiple smaller condensates. Here, we identify a kinase, KEY1, in the model alga <i>Chlamydomonas reinhardtii</i> that regulates pyrenoid condensate size and number dynamics throughout the cell cycle and is necessary for normal pyrenoid function and growth. Unlike wild type, <i>key1</i> mutant cells have multiple smaller condensates throughout the cell cycle that fail to dissolve during cell divisio","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-09T03:19:01.274Z","creation":"2026-06-09T03:08:08.603Z"},"accession":"S-EPMC12632510","cross_references":{"pubmed":["41278836"],"doi":["10.1101/2025.10.09.681382"]}}