{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Yang H"],"funding":["Intramural NIH HHS","NIA NIH HHS","NIH HHS"],"pubmed_abstract":["The dorsolateral prefrontal cortex (DLPFC) underpins higher cognitive functions and is highly susceptible to age-related decline. However, a comprehensive, lifespan-resolved map of its cellular and molecular programs has been lacking. Here, we constructed the first single-nucleus transcriptomic atlas of the human DLPFC, spanning the full lifespan, profiling over 1.3 million nuclei from 284 postmortem samples ranging in age from 0-97 years. This unprecedented resource reveals three distinct transcriptomic phases: dynamic developmental remodeling, midlife stability, and late-life molecular reactivation. Non-linear modeling of age trends uncovers ten distinct trajectories, including a neuronal resilience program peaking in early adolescence and glial aging programs marked by immune activation"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2024.11.06.24316592"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12632665"],"repository":["biostudies-literature"],"pubmed_title":["A lifespan transcriptomic atlas of the human prefrontal cortex at single-cell resolution."],"pmcid":["PMC12632665"],"funding_grant_id":["ZIC MH002903","R01 AG067025","R01 AG065582","R01 AG082185","75N95019C00049"],"pubmed_authors":["Auluck PK","Marenco S","Casey C","Venkatesh S","McClung CA","Lee D","Shao Z","Voloudakis G","Yu AK","Hoffman GE","Wang X","Murphy SR","Argyriou S","Yang H","Alvia M","Roussos P","Tsankova NM","Scott MR","PsychAD Consortium","Bendl J","Hong A","Fullard JF","Haroutunian V","Girdhar K","Pjanic M","Clarence T","Prashant NM"],"additional_accession":[]},"is_claimable":false,"name":"A lifespan transcriptomic atlas of the human prefrontal cortex at single-cell resolution.","description":"The dorsolateral prefrontal cortex (DLPFC) underpins higher cognitive functions and is highly susceptible to age-related decline. However, a comprehensive, lifespan-resolved map of its cellular and molecular programs has been lacking. Here, we constructed the first single-nucleus transcriptomic atlas of the human DLPFC, spanning the full lifespan, profiling over 1.3 million nuclei from 284 postmortem samples ranging in age from 0-97 years. This unprecedented resource reveals three distinct transcriptomic phases: dynamic developmental remodeling, midlife stability, and late-life molecular reactivation. Non-linear modeling of age trends uncovers ten distinct trajectories, including a neuronal resilience program peaking in early adolescence and glial aging programs marked by immune activation","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-01T03:16:50.909Z","creation":"2026-06-01T03:10:50.783Z"},"accession":"S-EPMC12632665","cross_references":{"pubmed":["41282859"],"doi":["10.1101/2024.11.06.24316592"]}}