{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Ouadah Y"],"funding":["NIDA NIH HHS"],"pubmed_abstract":["We have identified a <i>Drosophila</i> species which exhibits spontaneous and robust intermale sexual behavior. <i>D. santomea</i> males distinguish conspecific sexes but court both vigorously and seldom attack. Elevated intermale courtship stems from at least three evolutionarily derived pheromonal changes. In males, the sexually monomorphic cuticular pheromone 7-tricosene promotes rather than inhibits courtship and the courtship-inhibiting olfactory pheromone cVA is reduced 84-92% compared to close relatives. The third switch is in <i>D. santomea</i> females, where cVA suppresses rather than promotes sexual receptivity. Female cVA aversion and male cVA reduction may have co-evolved to maintain efficient intraspecific mating but prevent hybridization with the sympatric sibling species D<i"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.10.14.682417"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12632756"],"repository":["biostudies-literature"],"pubmed_title":["Evolutionary basis of intermale sexual behavior by multiple pheromone switches in &lt;i&gt;Drosophila&lt;/i&gt;."],"pmcid":["PMC12632756"],"funding_grant_id":["R37 DA031389"],"pubmed_authors":["Smihula H","Naragon TH","Ouadah Y","Behrman EL","Ding Y","Parker J","Anderson DJ","Khallaf MA","Stern DL"],"additional_accession":[]},"is_claimable":false,"name":"Evolutionary basis of intermale sexual behavior by multiple pheromone switches in &lt;i&gt;Drosophila&lt;/i&gt;.","description":"We have identified a <i>Drosophila</i> species which exhibits spontaneous and robust intermale sexual behavior. <i>D. santomea</i> males distinguish conspecific sexes but court both vigorously and seldom attack. Elevated intermale courtship stems from at least three evolutionarily derived pheromonal changes. In males, the sexually monomorphic cuticular pheromone 7-tricosene promotes rather than inhibits courtship and the courtship-inhibiting olfactory pheromone cVA is reduced 84-92% compared to close relatives. The third switch is in <i>D. santomea</i> females, where cVA suppresses rather than promotes sexual receptivity. Female cVA aversion and male cVA reduction may have co-evolved to maintain efficient intraspecific mating but prevent hybridization with the sympatric sibling species D<i","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-12T03:16:28.07Z","creation":"2026-06-12T03:07:55.464Z"},"accession":"S-EPMC12632756","cross_references":{"pubmed":["41279461"],"doi":["10.1101/2025.10.14.682417"]}}