{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Haldar T"],"funding":["BLRD VA","NHLBI NIH HHS"],"pubmed_abstract":["<h4>Background</h4>Polygenic risk scores derived from coronary artery disease genome-wide association studies are associated with statin relative risk reduction.<h4>Objective</h4>Examine the relationship between coronary artery disease polygenic risk scores that include variants below thresholds of genome-wide significance and statin primary prevention of major adverse cardiovascular events.<h4>Methods</h4>We generated coronary artery disease polygenic risk scores for participants with no past evidence of myocardial infarction from three electronic health record-linked genetic biobanks: All of Us Research Program, Genetic Epidemiology Research on Adult Health and Aging, and the Million Veteran Program. We scored each participant using three different polygenic risk scores: two with both ge"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2025.10.09.25337698"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12633136"],"repository":["biostudies-literature"],"pubmed_title":["Clinical validation of a statin-benefit polygenic score using real-world cohorts of primary prevention participants."],"pmcid":["PMC12633136"],"funding_grant_id":["I01 BX003362","R56 HL161518"],"pubmed_authors":["Risch N","Iribarren C","Toda N","Tsao PS","Voorhees AL","Popejoy AB","Iyer KR","Oni-Orisan A","Lu M","Douglas MP","Lynch JA","Najera JA","Tcheandjieu C","Chang KM","Lee KM","Haldar T","Bress A","Teerlink CC","Krauss RM"],"additional_accession":[]},"is_claimable":false,"name":"Clinical validation of a statin-benefit polygenic score using real-world cohorts of primary prevention participants.","description":"<h4>Background</h4>Polygenic risk scores derived from coronary artery disease genome-wide association studies are associated with statin relative risk reduction.<h4>Objective</h4>Examine the relationship between coronary artery disease polygenic risk scores that include variants below thresholds of genome-wide significance and statin primary prevention of major adverse cardiovascular events.<h4>Methods</h4>We generated coronary artery disease polygenic risk scores for participants with no past evidence of myocardial infarction from three electronic health record-linked genetic biobanks: All of Us Research Program, Genetic Epidemiology Research on Adult Health and Aging, and the Million Veteran Program. We scored each participant using three different polygenic risk scores: two with both ge","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-01T03:11:22.525Z","creation":"2026-06-01T03:06:44.175Z"},"accession":"S-EPMC12633136","cross_references":{"pubmed":["41282843"],"doi":["10.1101/2025.10.09.25337698"]}}