biostudies-literatureUnknownHaldar TBLRD VANHLBI NIH HHS<h4>Background</h4>Polygenic risk scores derived from coronary artery disease genome-wide association studies are associated with statin relative risk reduction.<h4>Objective</h4>Examine the relationship between coronary artery disease polygenic risk scores that include variants below thresholds of genome-wide significance and statin primary prevention of major adverse cardiovascular events.<h4>Methods</h4>We generated coronary artery disease polygenic risk scores for participants with no past evidence of myocardial infarction from three electronic health record-linked genetic biobanks: All of Us Research Program, Genetic Epidemiology Research on Adult Health and Aging, and the Million Veteran Program. We scored each participant using three different polygenic risk scores: two with both gemedRxiv : the preprint server for health sciences2025.10.09.25337698https://www.ebi.ac.uk/biostudies/studies/S-EPMC12633136biostudies-literatureClinical validation of a statin-benefit polygenic score using real-world cohorts of primary prevention participants.PMC12633136I01 BX003362R56 HL161518Risch NIribarren CToda NTsao PSVoorhees ALPopejoy ABIyer KROni-Orisan ALu MDouglas MPLynch JANajera JATcheandjieu CChang KMLee KMHaldar TBress ATeerlink CCKrauss RMfalseClinical validation of a statin-benefit polygenic score using real-world cohorts of primary prevention participants.<h4>Background</h4>Polygenic risk scores derived from coronary artery disease genome-wide association studies are associated with statin relative risk reduction.<h4>Objective</h4>Examine the relationship between coronary artery disease polygenic risk scores that include variants below thresholds of genome-wide significance and statin primary prevention of major adverse cardiovascular events.<h4>Methods</h4>We generated coronary artery disease polygenic risk scores for participants with no past evidence of myocardial infarction from three electronic health record-linked genetic biobanks: All of Us Research Program, Genetic Epidemiology Research on Adult Health and Aging, and the Million Veteran Program. We scored each participant using three different polygenic risk scores: two with both ge2025-01-01T00:00:00Z2025 Oct2026-06-01T03:11:22.525Z2026-06-01T03:06:44.175ZS-EPMC126331364128284310.1101/2025.10.09.25337698