{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Allison CV"],"funding":["NIDDK NIH HHS"],"pubmed_abstract":["<h4>Introduction</h4>Sex influences susceptibility, recovery, and long-term outcomes after acute kidney injury (AKI) in humans. Rodent models have been invaluable for elucidating AKI mechanisms; however, most studies have focused on males, assuming direct applicability to females, an assumption that remains largely untested. In males, the transcription factor SOX9 regulates injury-associated proximal tubule cell states, supporting survival during injury but also contributing to maladaptive repair. Given the well-described role of SOX9 in sex determination during development and its emerging importance in AKI, we investigated whether it mediates sex-specific tubular responses in the adult kidney.<h4>Methods</h4>We first optimized differential ischemic and cisplatin conditions in males and f"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.10.23.684153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12633231"],"repository":["biostudies-literature"],"pubmed_title":["Androgens Drive SOX9 Upregulation in Injured Proximal Tubular Cells."],"pmcid":["PMC12633231"],"funding_grant_id":["R56 DK140315","R01 DK142433","R01 DK132230"],"pubmed_authors":["Coss CC","Mallipattu SK","Rao R","Thorson VC","Kim J","Pabla NS","Silvaroli JA","Karel IZ","Allison CV","Patel PS","Humphreys BD","Bolisetty S","Bajwa A","Xuanyuan Q","Scindia Y","Stayton A","Thailammanal HJ","Sloane G","Zepeda-Orozco D"],"additional_accession":[]},"is_claimable":false,"name":"Androgens Drive SOX9 Upregulation in Injured Proximal Tubular Cells.","description":"<h4>Introduction</h4>Sex influences susceptibility, recovery, and long-term outcomes after acute kidney injury (AKI) in humans. Rodent models have been invaluable for elucidating AKI mechanisms; however, most studies have focused on males, assuming direct applicability to females, an assumption that remains largely untested. In males, the transcription factor SOX9 regulates injury-associated proximal tubule cell states, supporting survival during injury but also contributing to maladaptive repair. Given the well-described role of SOX9 in sex determination during development and its emerging importance in AKI, we investigated whether it mediates sex-specific tubular responses in the adult kidney.<h4>Methods</h4>We first optimized differential ischemic and cisplatin conditions in males and f","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-31T03:13:46.407Z","creation":"2026-05-31T03:09:53.842Z"},"accession":"S-EPMC12633231","cross_references":{"pubmed":["41279940"],"doi":["10.1101/2025.10.23.684153"]}}