{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kou H"],"funding":["NEI NIH HHS","NHLBI NIH HHS","National Institutes of Health"],"pagination":["24953-24962"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12633720"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(17)"],"pubmed_abstract":["Nanoparticle-based therapeutics hold promise for the treatment of atherosclerosis, but challenges such as low drug-loading capacity and a lack of scalable, controllable production hinder their clinical translation. Flash nanoprecipitation, a continuous synthesis method, offers a potential solution for scalable and reproducible nanoparticle production. In this study, we employed a custom-designed multi-inlet vortex mixer to perform cross-linking reaction-enabled flash nanoprecipitation, facilitating controlled and scalable synthesis of cross-linked polyamidoamine (PAMAM) dendrimer nanoparticles. Notably, this approach allows simultaneous nanoparticle cross-linking and drug loading in a single step. The mannose moiety enabled specific targeting of macrophages via mannose receptors, enhancing"],"journal":["ACS applied materials & interfaces"],"pubmed_title":["Scalable Fabrication of High-Payload Dendrimer-Based Nanoparticles for Targeted Atherosclerosis Therapy."],"pmcid":["PMC12633720"],"funding_grant_id":["R01HL140684","R01 HL140684","R01EY035088","R01 EY035088"],"pubmed_authors":["Yang H","Wu J","Qi L","Huang D","Kou H","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"Scalable Fabrication of High-Payload Dendrimer-Based Nanoparticles for Targeted Atherosclerosis Therapy.","description":"Nanoparticle-based therapeutics hold promise for the treatment of atherosclerosis, but challenges such as low drug-loading capacity and a lack of scalable, controllable production hinder their clinical translation. Flash nanoprecipitation, a continuous synthesis method, offers a potential solution for scalable and reproducible nanoparticle production. In this study, we employed a custom-designed multi-inlet vortex mixer to perform cross-linking reaction-enabled flash nanoprecipitation, facilitating controlled and scalable synthesis of cross-linked polyamidoamine (PAMAM) dendrimer nanoparticles. Notably, this approach allows simultaneous nanoparticle cross-linking and drug loading in a single step. The mannose moiety enabled specific targeting of macrophages via mannose receptors, enhancing","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-05T18:41:28.65Z","creation":"2026-05-20T03:13:43.017Z"},"accession":"S-EPMC12633720","cross_references":{"pubmed":["40237537"],"doi":["10.1021/acsami.5c00816"]}}