biostudies-literatureUnknown16Wen Y<h4>Background</h4>The prognostic significance of long non-coding RNA ST8SIA6-AS1 remains ambiguous, and its biological role in prostate cancer (PCa) has not been thoroughly investigated. This study seeks to conduct a comprehensive meta-analysis to assess the clinical relevance of ST8SIA6-AS1 across different malignancies, with a particular emphasis on elucidating its functions in the advancement of PCa.<h4>Methods</h4>Systematic searches were conducted in the PubMed, Embase, and Web of Science databases to select studies that met the criteria. Data, including hazard ratios (HR) with 95% confidence intervals (95% CI) and clinical pathological parameters, were collected. Subgroup analyses were performed based on sample size and tumor type. The expression profile analysis of PCa tissues was Frontiers in genetics1648077https://www.ebi.ac.uk/biostudies/studies/S-EPMC12634032biostudies-literatureST8SIA6-AS1 serves as a prognostic biomarker in cancer and exhibits oncogenic properties in prostate cancer.PMC12634032Wen YYang JHuang YZhan SChen GZheng SZhu SfalseST8SIA6-AS1 serves as a prognostic biomarker in cancer and exhibits oncogenic properties in prostate cancer.<h4>Background</h4>The prognostic significance of long non-coding RNA ST8SIA6-AS1 remains ambiguous, and its biological role in prostate cancer (PCa) has not been thoroughly investigated. This study seeks to conduct a comprehensive meta-analysis to assess the clinical relevance of ST8SIA6-AS1 across different malignancies, with a particular emphasis on elucidating its functions in the advancement of PCa.<h4>Methods</h4>Systematic searches were conducted in the PubMed, Embase, and Web of Science databases to select studies that met the criteria. Data, including hazard ratios (HR) with 95% confidence intervals (95% CI) and clinical pathological parameters, were collected. Subgroup analyses were performed based on sample size and tumor type. The expression profile analysis of PCa tissues was 2025-01-01T00:00:00Z20252026-05-19T03:21:16.245Z2026-05-19T03:11:49.661ZS-EPMC126340324128248610.3389/fgene.2025.1648077