{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Visentin A"],"funding":["Università degli Studi di Padova (University of Padova)","Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research)"],"pagination":["2957-2967"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12634426"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(12)"],"pubmed_abstract":["In chronic lymphocytic leukemia (CLL), the role of complex karyotype (CK) for prognostic stratification remains a topic of debate, and the impact of specific cytogenetic abnormalities is still unclear. This study aims to investigate the clinical and biological features of CLL with t(14;19)(q32;q13) (tCLL) involving the BCL3 gene. Patients with tCLL were younger and more commonly presented unmutated IGHV gene, subset #8 stereotypy, trisomy of chromosome 12, and complex karyotype than other patients without t(14;19) (oCLL). The presence of t(14;19) was associated with a shorter time to treatment and overall survival compared to oCLL. Gene expression analysis revealed a unique transcriptome profile in tCLL, characterized by the upregulation of BCL3 and the activation of B-cell receptor, PI3K-"],"journal":["Leukemia"],"pubmed_title":["Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study."],"pmcid":["PMC12634426"],"funding_grant_id":["Be_CL3VER","IG-25024","21198"],"pubmed_authors":["Cuneo A","Davis Z","Puiggros A","Trentin L","Kater A","Orsi S","Roncaglia E","Baran-Marszak F","Yi S","Serafin A","Woyach JA","Haferlach C","Terol MJ","Scarfo L","Doubek M","Bortoluzzi S","Miller C","Ghia P","Cui C","Rigolin GM","Stamatopoulos K","Abrisqueta P","Martines A","Chatzikonstantinou T","Panagiotidis P","Kalashnikova O","Cellini A","Espinet B","Valiente A","Bonaldi L","Kreuzer KA","Eichhorst B","Oscier D","Furstenau M","Calabretto G","Athanasiadou A","Frezzato F","Nguyen-Khac F","Visentin A","Gaffo E","Mauro FR","Bosch F","Panagiotis B","Tausch E","Ruocco V","Angotzi F","Rogers KA","Plevova K"],"additional_accession":[]},"is_claimable":false,"name":"Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study.","description":"In chronic lymphocytic leukemia (CLL), the role of complex karyotype (CK) for prognostic stratification remains a topic of debate, and the impact of specific cytogenetic abnormalities is still unclear. This study aims to investigate the clinical and biological features of CLL with t(14;19)(q32;q13) (tCLL) involving the BCL3 gene. Patients with tCLL were younger and more commonly presented unmutated IGHV gene, subset #8 stereotypy, trisomy of chromosome 12, and complex karyotype than other patients without t(14;19) (oCLL). The presence of t(14;19) was associated with a shorter time to treatment and overall survival compared to oCLL. Gene expression analysis revealed a unique transcriptome profile in tCLL, characterized by the upregulation of BCL3 and the activation of B-cell receptor, PI3K-","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T19:51:57.947Z","creation":"2026-06-04T03:12:48.881Z"},"accession":"S-EPMC12634426","cross_references":{"pubmed":["40973766"],"doi":["10.1038/s41375-025-02755-8"]}}