biostudies-literatureVisentin AUniversità degli Studi di Padova (University of Padova)Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research)2957-2967https://www.ebi.ac.uk/biostudies/studies/S-EPMC12634426biostudies-literatureUnknown39(12)In chronic lymphocytic leukemia (CLL), the role of complex karyotype (CK) for prognostic stratification remains a topic of debate, and the impact of specific cytogenetic abnormalities is still unclear. This study aims to investigate the clinical and biological features of CLL with t(14;19)(q32;q13) (tCLL) involving the BCL3 gene. Patients with tCLL were younger and more commonly presented unmutated IGHV gene, subset #8 stereotypy, trisomy of chromosome 12, and complex karyotype than other patients without t(14;19) (oCLL). The presence of t(14;19) was associated with a shorter time to treatment and overall survival compared to oCLL. Gene expression analysis revealed a unique transcriptome profile in tCLL, characterized by the upregulation of BCL3 and the activation of B-cell receptor, PI3K-LeukemiaClinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study.PMC12634426Be_CL3VERIG-2502421198Cuneo ADavis ZPuiggros ATrentin LKater AOrsi SRoncaglia EBaran-Marszak FYi SSerafin AWoyach JAHaferlach CTerol MJScarfo LDoubek MBortoluzzi SMiller CGhia PCui CRigolin GMStamatopoulos KAbrisqueta PMartines AChatzikonstantinou TPanagiotidis PKalashnikova OCellini AEspinet BValiente ABonaldi LKreuzer KAEichhorst BOscier DFurstenau MCalabretto GAthanasiadou AFrezzato FNguyen-Khac FVisentin AGaffo EMauro FRBosch FPanagiotis BTausch ERuocco VAngotzi FRogers KAPlevova KfalseClinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study.In chronic lymphocytic leukemia (CLL), the role of complex karyotype (CK) for prognostic stratification remains a topic of debate, and the impact of specific cytogenetic abnormalities is still unclear. This study aims to investigate the clinical and biological features of CLL with t(14;19)(q32;q13) (tCLL) involving the BCL3 gene. Patients with tCLL were younger and more commonly presented unmutated IGHV gene, subset #8 stereotypy, trisomy of chromosome 12, and complex karyotype than other patients without t(14;19) (oCLL). The presence of t(14;19) was associated with a shorter time to treatment and overall survival compared to oCLL. Gene expression analysis revealed a unique transcriptome profile in tCLL, characterized by the upregulation of BCL3 and the activation of B-cell receptor, PI3K-2025-01-01T00:00:00Z2025 Dec2026-06-06T19:51:57.947Z2026-06-04T03:12:48.881ZS-EPMC126344264097376610.1038/s41375-025-02755-8