{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Jain A"],"pubmed_abstract":["<h4>Introduction</h4>The endangered orchid <i>Dendrobium nobile</i> is the primary source of dendrobine, a neuroprotective sesquiterpene alkaloid, but unsustainable harvesting necessitates alternative production platforms, such as the endophytic fungus <i>Trichoderma longibrachiatum</i> MD33. However, the fungal dendrobine pathway and its regulatory mechanisms remain uncharacterized, limiting its biotechnological exploitation.<h4>Methods</h4>This study investigated cinnabar (HgS)-induced hormesis to elucidate the stress-mediated metabolic reprogramming of dendrobine biosynthesis through integrated transcriptomic and metabolomic profiling.<h4>Results</h4>Subtoxic HgS concentrations (1.0-4.0 μg/L) triggered ROS signaling, upregulating the mevalonate pathway, terpenoid synthases (TPS1/2), and"],"journal":["Frontiers in microbiology"],"pagination":["1657982"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12634576"],"repository":["biostudies-literature"],"pubmed_title":["Cinnabar-induced hormesis in &lt;i&gt;Trichoderma longibrachiatum&lt;/i&gt; MD33: multi-omics elucidation of a fungal-specific dendrobine biosynthesis pathway."],"pmcid":["PMC12634576"],"pubmed_authors":["Jain A","Sarsaiya S","Gong Q"],"additional_accession":[]},"is_claimable":false,"name":"Cinnabar-induced hormesis in &lt;i&gt;Trichoderma longibrachiatum&lt;/i&gt; MD33: multi-omics elucidation of a fungal-specific dendrobine biosynthesis pathway.","description":"<h4>Introduction</h4>The endangered orchid <i>Dendrobium nobile</i> is the primary source of dendrobine, a neuroprotective sesquiterpene alkaloid, but unsustainable harvesting necessitates alternative production platforms, such as the endophytic fungus <i>Trichoderma longibrachiatum</i> MD33. However, the fungal dendrobine pathway and its regulatory mechanisms remain uncharacterized, limiting its biotechnological exploitation.<h4>Methods</h4>This study investigated cinnabar (HgS)-induced hormesis to elucidate the stress-mediated metabolic reprogramming of dendrobine biosynthesis through integrated transcriptomic and metabolomic profiling.<h4>Results</h4>Subtoxic HgS concentrations (1.0-4.0 μg/L) triggered ROS signaling, upregulating the mevalonate pathway, terpenoid synthases (TPS1/2), and","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-19T03:23:09.854Z","creation":"2026-05-19T03:12:00.481Z"},"accession":"S-EPMC12634576","cross_references":{"pubmed":["41277980"],"doi":["10.3389/fmicb.2025.1657982"]}}