{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(1)"],"submitter":["He S"],"pubmed_abstract":["Intestinal ischemia‑reperfusion (I/R) injury is a clinical condition that leads to severe intestinal damage, inflammation and oxidative stress. While cathepsin B (<i>CTSB</i>) has been implicated in these pathophysiological processes, its precise role in mediating I/R‑induced injury remains poorly understood. The present study aimed to elucidate how <i>CTSB</i> knockdown influences oxidative stress, inflammatory responses and the integrity of the intestinal epithelial barrier in intestinal epithelial Caco‑2 cells subjected to I/R injury. To identify key genes implicated in I/R injury, a comprehensive analysis was conducted using differential expression profiling and protein‑protein interaction network analysis of the GSE37013 dataset. To simulate I/R damage<i> in vitro</i>, an oxygen‑gluco"],"journal":["Molecular medicine reports"],"pagination":["39"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12635601"],"repository":["biostudies-literature"],"pubmed_title":["&lt;i&gt;CTSB&lt;/i&gt; mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury."],"pmcid":["PMC12635601"],"pubmed_authors":["Jiang Y","He S","Yu S","Xiang H","Wang Z","Zhu Q","Wu Y","Wang L","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;CTSB&lt;/i&gt; mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury.","description":"Intestinal ischemia‑reperfusion (I/R) injury is a clinical condition that leads to severe intestinal damage, inflammation and oxidative stress. While cathepsin B (<i>CTSB</i>) has been implicated in these pathophysiological processes, its precise role in mediating I/R‑induced injury remains poorly understood. The present study aimed to elucidate how <i>CTSB</i> knockdown influences oxidative stress, inflammatory responses and the integrity of the intestinal epithelial barrier in intestinal epithelial Caco‑2 cells subjected to I/R injury. To identify key genes implicated in I/R injury, a comprehensive analysis was conducted using differential expression profiling and protein‑protein interaction network analysis of the GSE37013 dataset. To simulate I/R damage<i> in vitro</i>, an oxygen‑gluco","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T06:33:23.883Z","creation":"2026-06-06T03:07:00.55Z"},"accession":"S-EPMC12635601","cross_references":{"pubmed":["41235676"],"doi":["10.3892/mmr.2025.13749"]}}