{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sherifali DT"],"funding":["Heather M Arthur Population Health Research Institute/Hamilton Health Sciences","Canadian Institutes of Health Research","CIHR"],"pagination":["2181-2191"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12635883"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(12)"],"pubmed_abstract":["<h4>Background</h4>Evidence that type 2 diabetes can be reversed has been limited by the understanding and implementation of these interventions.<h4>Purpose</h4>We assessed the effect of nonsurgical randomized controlled trials (RCTs) on type 2 diabetes remission and characterized core components.<h4>Data sources</h4>We reviewed articles from MEDLINE and Embase (inception to April 2025).<h4>Study selection</h4>RCTs of multimodal pharmacological or nonpharmacological type 2 diabetes remission interventions for adults with type 2 diabetes were included.<h4>Data extraction</h4>Study characteristics and outcomes for clinical/population health, patient-reported, and adverse event were extracted.<h4>Data synthesis</h4>We performed a random-effects multilevel meta-analysis of studies, grouped bas"],"journal":["Diabetes care"],"pubmed_title":["Type 2 Diabetes Remission: A Systematic Review and Meta-analysis of Nonsurgical Randomized Controlled Trials."],"pmcid":["PMC12635883"],"funding_grant_id":["KM2-196997"],"pubmed_authors":["Racey ME","Ali MU","Roglich J","Gerstein HC","Rabi D","Kim J","Chouinor K","Emond R","Ewer M","Greenway MK","Sherifali DT","Nerenberg K","Sherifali D","Dasgupta K","Integrated Knowledge Translation (iKT) Type 2 Diabetes Remission Advisory Team*","Kastner M","Honshort K","McKenna B","McInnes N","Lipscombe L","Lamb K","McQuire T","Racey M","Gamble JM","McKelvey S","Brown J","Fitzpatrick-Lewis D","Punthakee Z","Alliston PE","Chiavaroli L","Alliston P","Makarski J","Gerstein H"],"additional_accession":[]},"is_claimable":false,"name":"Type 2 Diabetes Remission: A Systematic Review and Meta-analysis of Nonsurgical Randomized Controlled Trials.","description":"<h4>Background</h4>Evidence that type 2 diabetes can be reversed has been limited by the understanding and implementation of these interventions.<h4>Purpose</h4>We assessed the effect of nonsurgical randomized controlled trials (RCTs) on type 2 diabetes remission and characterized core components.<h4>Data sources</h4>We reviewed articles from MEDLINE and Embase (inception to April 2025).<h4>Study selection</h4>RCTs of multimodal pharmacological or nonpharmacological type 2 diabetes remission interventions for adults with type 2 diabetes were included.<h4>Data extraction</h4>Study characteristics and outcomes for clinical/population health, patient-reported, and adverse event were extracted.<h4>Data synthesis</h4>We performed a random-effects multilevel meta-analysis of studies, grouped bas","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-20T03:23:43.441Z","creation":"2026-05-20T03:14:53.003Z"},"accession":"S-EPMC12635883","cross_references":{"pubmed":["40982327"],"doi":["10.2337/dc25-0562"]}}